New family of drugs which could combat prostate cancer identified at University of Bath

[GranPaSmurf]

A new family of drugs which inhibit the activity of a protein associated with prostate and other cancers has been reported by scientists from the University of Bath.

They provide a promising avenue for research to potentially develop new therapies to treat a range of cancers thanks to the design of the study, which rationally investigates how the drugs work. The research team from the Departments of Pharmacy & Pharmacology and Chemistry study a protein called α-methylacyl-CoA racemase (AMACR). Levels of the AMACR protein and its activity are increased by ~10-fold in all prostate cancers, and a number of other cancers as well.

Reducing levels of AMACR in prostate cancer cells using genetic techniques makes them less aggressive, and their behaviour becomes more like normal cells.

eurekalert.org/pub_releases...

[Magnus1964]

Thanks for sharing.

[Jbooml]

fascinating...i was digging around looking at a rare PC called pseudohypertrophic and its marked by high amacr.....so we have another marker to target....good.

Simplest is best....psma is so promising but so evasive and somewhat complicated. maybe this will prove simply fruitful.

What will Tall Allen say.

[George71]

Thanks for the post -- good stuff !

[Currumpaw]

Thank you!

Currumpaw

[tallguy2]

Thanks for posting this!