Pluvicto failed - what is next?

Hello Warriors

Well it looks like pluvicto has failed. I just got my most recent PSA test after my fourth injection and my PSA has now gone from 20 to 30. Also my PSMA scan says that my cancer is no more stable and on the move with more tracers. Still just in the bones.

Pluvicto was brutal on my body. Extreme fatigue, dry mouth, terrible. G.I. issues with diarrhea,.

I see my oncologist on Monday and I hope he has another step for me to try. I know many of you are in my same predicament and I wonder what you’ve done. Please let me know.

Thank you so much for your input. Tom.

[Kaliber]

I’m no doctor and I don’t even play one on TV , but seems like you might get a temporary boost in PSA from all the killed ones entering your blood stream from the treatments. Maybe , after you wait a bit for the treatment to settle and everything normalize….. then you’ll have a better understanding of what is happening and where you stand. TA is the brain on this stuff …. just some random thoughts IMHO brother.

❤️❤️❤️

[Hidden in reply to Kaliber]

Thanks Kaliner.

I so appreciate your input. The Lord has blessed me with 21 years on this earth since my diagnosis.

Sure hope something can slow it down.really appreciate your input Tom.

[Kaliber in reply to Hidden]

❤️❤️❤️

[Tall_Allen]

I'm sorry Pluvicto was a dud for you. Maybe some combination with Xofigo if your blood work has recovered?

prostatecancer.news/2021/02...

[Hidden in reply to Tall_Allen]

Thanks T a I had Xofigo before Pluvicto

[Tall_Allen]

You can do it again:

onlinelibrary.wiley.com/doi...

Or maybe a biopsy and some metastatic tissue analysis will reveal an appropriate clinical trial.

[Yadifan]

Hi Tom

Sorry Pluvicto didn't help you. My husband was able to complete all 6 treatments but PSA started rising after dose #5. 4 month break after treatment #6 and started chemo again. He just completed cycle #3 of cabazitaxel. The plan is for 2 more chemo treatments and then radiation to an area on his skull - eye socket & jaw area that's seeing some growth. Possibly xofigo in the future if his blood counts are healthy enough. Our MO feels that he needs more time after Pluvicto.

It seems that there's quite a few here that have had unfavorable results with Pluvicto. Disappointing and alarming in some cases. Still a treatment that holds a lot of promise. But chemo is where we're at right now.

Please keep us posted. Best of luck and health to you.

Marie

[Hidden in reply to Yadifan]

is the chemo helping. Appreciate your input.

[Yadifan in reply to Hidden]

Hi Tom

The chemo seems to be helping. His PSA has dropped from 17.1 to 13.2 to 11.5 last week. He's tolerating it well so far.

We're all anxious to hear from you after your appointment and what your treatment plan will be. Take care!

[Hidden in reply to Yadifan]

Hi Yadifan:

I had the appointment with my MO this morning. He did not get too excited. He said I have run my course with Plavicto so we're going to stop. I'm going to rest my body for 45 days, get a blood infusion or two and then start capitaxal. He said his goal is to knock the cancer down again and hopefully I can get 8 months out of this treatment like I did with docetaxel.

What are your husband's side effects? Let's stay in touch. So appreciate your input.

Tom

[Yadifan in reply to Hidden]

Hi Tom

Ask your MO at your next appointment about a prescription to help with nausea. The cabazitaxel seems to be similar to docetaxel as far as side effects. Maybe even a little more tolerable. My husband is doing well on it so far. A little fatigue and his appetite isn't great but not too bad. Fruits - especially melons - seems to always sound good when nothing else does.

It sounds like your MO has a good plan. We like ours a lot and are grateful to him and his team. Hoping for positive results for you. Yes...let's stay in touch.

[Hidden in reply to Yadifan]

So appreciate your input. I will keep you posted. Tom

[Carlosbach in reply to Hidden]

Praying that the capitaxel is a success and that your body rebounds quickly

[Hidden in reply to Carlosbach]

Thank you so much Carlosbach.

[PacMan1950]

Oh Tom, I was sure that you had it nailed so I'm devastated to read your update.As you know my Lu-177 was stopped after treatment #2.

I went back to Chemo (Carboplatin) as Cabazitaxel had stopped working for me. My PSA was over 1100 last week!

My previous Chemo was a bag of Carboplatin followed by a bag of Docetaxel. I'm so weak these days that I just didn't have the strength to battle so much Chemo in one hit. I ended up in hospital for 3 days. It nearly killed me. I'm never, ever doing a double-bagger again.

I have been put on a list of candidates for a future Actinium trial at St. Vincent's Hospital in Sydney Australia.

The more I think about the SE's of the Actinium though, the more reluctant I am to try it.

At the moment I still have a bit of Q in my QOL 😉

I'm unsure where my current pathway is leading me and I don't think I'm going to like it when I get there.

Tom, I'll let you know if my plan changes.

Paul

[Hidden in reply to PacMan1950]

thanks so much Paul. We are all in this together.

Please keep me posted. Thanks, Tom.

[Yank66]

Please let us know what your MO recommends. We’re a couple of steps behind you and unsure of what’s next in line. Pluvicto “ helped kick the can down the road” as the doctor said. (Scans in November)

[Seebs9]

Don't give up yet...the fat lady has yet to sing. My Oncologist says they are seeing ups and downs in PSA readings. Keep going!

[Meshel48]

My Husband finish #6 of Pulvicto We had a appointment with his MO about 3 weeks after complete since the pain in his back was increasing. His MO thought a MRI of the spine would be good since that was what brought him in originally (fractured back from tumor ) had a Spine Myelography and PET CT Pylarify Skull to thigh . The Pulvicto got the old tumors that light up but had new larger ones lower on spine and rib left side. Plus when going thru Pluvicto our old MO changed and no longer took Medicare Addvantage so our new MO had him do Genetic testing since his Mom, Aunts, Uncle, and cousins had cancer and had pass away from it. And results came back at the same time that Pulvicto wasn't helping . And he had tested Positive for BRCA2 . So now he is on Orgovyx 120mg and trying to get insurance to approve Lynparza . They deny everything ! Orgovyx at first because he was on Pulvicto but once complete they filled. Now they denied Lynparza because they said he needs to be surgical castrated . I told them he is stage 4 mestastic - resistant PC. So that is our new treatment plus he is also going to get some beam radiation on those new spots and hope that it helps with pain and stops them in their tracks. And his PSA went up to 44.3 from 21.1 in one month. but the worst was his testosterone was 374 after being off Lupron for a year so we hope with being on orgovyx that it will go down. I am sorry if that was to much info .

[Hidden in reply to Meshel48]

Oh Meshel58

Thank you so much for sharing. We are all in this battle together. I’m not familiar with orgovyx. my wife and I saw my MO today. He did not get too excited. He told us the pluvicto has run its course and we’re going to stop. He suggested I take a month and a half off and then go onto cabadaxel for four or five sessions. I agreed. I just want to get this crap out of my G.I. system. That is driving me crazy let’s keep in touch. Thanks so much for your input. Tom.

[Meshel48 in reply to Hidden]

Orgovyx is just like Lupron but pill form so side effects are not as bad and if you have them as soon as you quit taking the pill it is out of your system. When you get injection some are 3 month or 1 month so it's harder on the body and my husband would get HBP and blood sugar was really high from these medications . Yes these medications are tough ! Hope everything settles down for you! Michelle

[Mw921000000 in reply to Meshel48]

How long has your husband been castrate resistant for? Please keep us updated with his progress 🙏🏻