Surgery While on Xtandi/Eligard

I have been on Xtandi/Eligard now for about 5 months. At a psa of around 1.9 last March psma pet picked up 3 nodules in my lungs. All less than a cm. I am hormone sensitive and my current psa is undetectable.

This July I had a ct scan of chest/abdomen/pelvis. The mets in the lung have decreased in size, which is great, but they picked up a 3cm mass on my left kidney. A followup scan indicates renal cell carcinoma. Likely stage 1. Easily resectable and I do not lose the entire kidney.

I have been walking 10,000 steps a day or more everyday for a long time (about two years now). Everytime i get a little foggy/tired from the hormones I move and it feels better.

So my concern with this surgery is how fast i will recover while on hormones. My next eligard shot coincidentally is the week after surgery.

Do I take it or wait a month? Do i stop xtandi for a week or two whilst i heal from the partial nephrectomy?

Anyone with similar experience? I would think that the two drs would coordinate (same hospital) but they seemingly don’t.

[EdBar]

I don’t think that you stop either drug. But ask your doctors, and talk to them about coordinating with one another. Back in 2015 I had extensive Mohs surgery to remove melanoma while I was receiving chemo per CHAARTED and taking Xtandi and Lupron. My MO and surgeon stayed in communication since there was a danger of the chemo affecting my WBC counts. I think if you speak with both about communication they’ll come around otherwise you’ll have to be the intermediary.

Ed

[tarhoosier]

I had hip replacement in July and my MO suggested to stop Xtandi a day or two prior to surgery because of unknown interaction, mostly for anaesthesia drugs. A reasonable request and the anaesthesiologist made no comment about any drug interactions so I suspended for two days and all went well.

[j-o-h-n]

picked up 3 nodules in my lungs.

Keytruda cured my lung melanoma metastasis........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 09/02/2023 3:10 PM DST

[JD-guy]

Good morning, I am on Lupron and Xtandi, I had partial knee replacement in May 2023. I needed to get clearance from my PCP, and my Cardiogist, they only said to ask my MO for his recommendation for taking my meds. I was in the middle of a 3 month cycle for my Lupron, no problems there. The Xtandi, they said I could stop it for like 2 weeks, if I wanted to, but it was up to me. I decided to do a 1/2 dose for a week and then went back to full dose, 160mg. All went well and I must say, I had very little brain fog the week after my surgery. This is just my experience and what I did, ask your dr and listen to him. If you cannot get the two drs to talk to each other, be the advocate between them. I am not a Dr just another man along this journey trying to make the best of this cancer. All the best to you.

Keith

[Hidden]

So this is how it went for those interested in history at this point

1) I stayed on xtandi the entire time except for the one overnight in the hospital

2) Two weeks out and i am almost back to my normal self. I have gotten back up to 10000 steps/day three times in the last 5 days. Have to do the steps in increments. I normally walk 5000 steps right away in the am, but i found if i did that i was tired all day like I had walked 20000 steps. So 1000 steps per hour gets it done.