Post radiation psa

[Ayra1]

Seeking advice for father. RP in 2014 with clear margins and periprostatic node positive. After 2 years psa jumped to 2. A solitary met in femur. Sbrt given plus ADT started in feb 2017. Psa remained <.008 on ADT. Since nov 2019 psa started increasing till .09 when pana showed a solitary met on humerus. T was 19. We have been advised sbrt To humerus plus zytiga. Post 4 week sbrt psa is .05. Any suggestions if sbrt was effective and if we can delay zytiga or start it right away

[Tall_Allen]

Of course, start Zytiga ASAP. All you have accomplished by zapping the bone met is treating PSA - that is not the same as treating the cancer.

[Ayra1 in reply to Tall_Allen]

Thank u

[paritosh1010 in reply to Tall_Allen]

Is there benefit in delaying zytiga - for instance would it give a prolonged response down the line?

[Tall_Allen in reply to paritosh1010]

The opposite - it has the greatest effect when used earlier, diminishing over time. That seems to be true of almost all prostate cancer medications.

[Ayra1]

Thank u