ORIC 944 trial

[Magnus1964]

I have just been accepted into the ORIC 944 drug trial. Is anyone else on this trial and would you share your experiences either on the forum or through the Chat feature?

Magnus

[Hidden]

Best of luck to you.

[GSDF]

Prayers for you Mag 🙏. Please keep us updated brother...

[Cooolone]

No knowledge of this until your post, read the trial profile and want to wish you the Best of Luck and Regards!

[Bethpage]

Hoping you get some responses. I'm wishing you best results from the trial.

[j-o-h-n]

Be fair..... hit them below the belt..........

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 05/26/2023 10:31 PM DST

[dhccpa]

Best of luck. You have had quite a journey.

[CAMPSOUPS]

Hope this goes very well for you.

[Graham49]

You are my hero. Good luck.

[Seasid]

This is the link to the trial. I personally would not participate in phase I trial. Too risky. Of course if the phase I trial s a combination of already approved treatments than I would reconcider it. You do not really know te effective dose or the toxicity of any dose. Could you find a phase II trial? Or wait until this trial progress to phase II? In my hospital they offer a phase II BAT trial with Carboplatin. Did you have a liquid biopsy to see if you have BRCA mutations?

classic.clinicaltrials.gov/...

[Magnus1964 in reply to Seasid]

I have been on two phase III trials. At this time I'll take what I get. I know the risks.

I've been at this for 30 years. I heading for the last round up.

[Seasid in reply to Magnus1964]

Who advised you?

[Magnus1964 in reply to Seasid]

My research doctor

[Seasid in reply to Magnus1964]

Thanks.

Could you ask him to off you phase II trials?

In phase I there is dose escalation and you don't know if the dose is safe or even effective. Could you get guardant 360 liquid biopsy and see if some standard of care solution is still available for you?

PARP inhibitors (olaparib) or Keytruda or BAT alone or with something else? Or could you just join to your trial at phase two ones they know at least that the dose is effective but not toxic? I personally would not rush with any clinical trial even if it is phase 3.

[Seasid in reply to Seasid]

classic.clinicaltrials.gov/...

[Seasid in reply to Seasid]

Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer (CYPIDES)

[Seasid in reply to Seasid]

Study locations :United States, Maryland

University of Maryland Marlene and Stewart Greenebaum Cancer Center Recruiting

Baltimore, Maryland, United States, 21201

United States, Minnesota

Masonic Cancer Center, University of Minnesota Recruiting

Minneapolis, Minnesota, United States, 55455

United States, Nebraska

Nebraska Cancer Specialists Recruiting

Omaha, Nebraska, United States, 68114

United States, New York

University at Buffalo, Kaleida Health Great Lakes Cancer Care Collaborative Recruiting

Buffalo, New York, United States, 14203

Finland

Helsinki University Central Hospital Recruiting

Helsinki, Finland

Tampere University Hospital Recruiting

Tampere, Finland

[swwags]

No experience but I wish you the best of luck

[shaunaliz15]

Did you have any luck finding anyone who was on this trial (we are considering this)? I did see you didn't move forward with it, but wondered what you heard/learned if anything. Thank you!

[Magnus1964]

I was taken off the trial do to a secondary cancer.