I will be starting a combination therapy trial through Yale using B.A.T. And Provenge. This is the first time I’ve heard of such a combo. There are only 6 of us in this trial.
Is there anyone else on this trial or have any experience with using both treatments?
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No_stone_unturned
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I contacted them a while back. But they never got back to me. I'm actually doing an exBAT protocol similar to the Trial in Brazil. Instead of Cypionate I'm using Propionate, which washes out more quickly thus achieving a true castrate low. I would think BAT and Provenge would stress the cancer nicely.,
There are two types of man made Testosterone that I am aware of. Cypionate and Propionate. Propionate has a short half life and washes out of the body quickly. Cypionate can last up to 6 weeks in the body. Decay is very slow.
Extreme bipolar androgen therapy with darolutamide and testosterone cypionate in patients with metastatic castration-resistant prostate cancer: ExBAT (LACOG 0620) trial.
The theory is that BAT may create double-strand breaks in the DNA of the prostate cancer which might prime a stronger immunological response. Similar trials that test out this theory are pairing BAT with medicines that are also known to induce double-strand breaks or may modify the immune microenvironment, like Xofigo and Carboplatin, to get a more complete response. They are also testing it on patients that have genomic repair defects like BRCA, ATM, CDK12 or CHK2 because the DNA damage might be irreparable.
Participants will start with testosterone injection every 4 weeks. The first dose of standard of care Sipuleucel-T will be prepared and infused after two doses of testosterone and will continue every 2 weeks for a total of 3 infusions at a standard schedule. The testosterone injection will continue once every 4 weeks until treatment discontinuation criteria are met.
Thanks - I see the misunderstanding. That is how all BAT trials are done. ADT continues throughout. That's what makes it bipolar. The way it works is the testosterone cypionate has a half-life of only 8 days so there is no exogenous testosterone left in the blood after a couple of weeks. So, it alternates between a boost of high testosterone every 4 weeks and no testosterone towards the end of the 4-week cycle.
Boy, were my expectations off. Here I thought I’d get a burst of limbido and energy and conversely I got 6-7 days of tumor pain. Apparently quite par for the course. Next shot I will be more prepared with a pain management plan.
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