Hi All
Three months after finishing docetaxel my husband’s PSA has risen from 0.3 to 3.4, which the oncologist tells us indicates that the cancer cells are active again, although he’s booked him for a PSMA PET scan to confirm this. We were hoping for at least a year without the need for any more treatment other than ADT. Has anyone had a similar experience and if so what were you given as a subsequent treatment? Our oncologist has given us the choice of abi or enza. Grateful for any feedback.
abi -> enza might last longer than enza->abi
prostatecancer.news/2019/12...
Thanks for your response, it is interesting that in England if you take enza for more than 12 weeks then you can’t then go on to take abi, and vice versa, presumably this is not the view in the US?
No, there is no such restriction in the US.
My husband started abiraterone immediately after docetaxel, and his PSA went from 0.99 right after treatment, to 4.16 only 3 months later. He then had scans and started on Jevtana/carboplatin.
So his response to docetaxel was short lived.
My brother, on the other hand, had an incomplete response to docetaxel, with his lowest PSA of 17, and immediately began climbing and 4 months later it was 205. He has had a great response to Pluvicto, however, with his PSA dropping to 1.35 after only 2 doses.
Hi im in England, I'll have to ask my Oncologist, cos I've been on enza over 12 weeks and no one has said i can't go on to Abi, i understand that's probably my next drug as enza is packing up working for me, i shall have to ask.
Definitely worth asking as our onco was very clear that it wasn’t an option. He said if it fails with one it’s likely to fail with the other. This is at odds with what happens in the US so we’ll definitely be questioning this when we see him next.
It's a restriction by the NHS. If you go private you should get a lot more options.
Thank you i have to see my Oncologist beginning of June, so i will definitely ask about that cos the Enzo is stopping working on me now and i don't fancy going down the chemo route, so thanks for highlighting that, and the next reply from Benkaymel, there's no way i can afford private.
I started with Lupron, then had six infusions of Taxotere. My PSA kept dropping for another couple of months, then started to slowly rise. Seven months later it had doubled from nadir, so I was started on abiraterone and Jevtana. I got very good results from that. The last Jevtana infusion was 26 months ago. I am still on daily abiraterone and quarterly Lupron. My PSA is currently <0.01.
Interesting about Jevtana and then continuing with abi and Lupron. I thought Jevtana was for CRPCa?
When my PSA doubled from nadir while on Lupron, I was then considered castrate-resistant. Abiraterone was the next layer of therapy, but I qualified for (and enrolled in) the CHAARTED2 clinical trial, which got me started on Jevtana as well, instead of waiting for further disease progression.
my hubby is getting Lupron injections every six months and his PSA is rising to 16. Does that infusion drug have bad side effects?
Chemotherapy with docetaxel (Taxotere) was not nearly as bad as I had feared before I started. I had many of the most common side effects: additional fatigue, hair loss, changes in taste perception, some muscle weakness, some nausea, some neuropathy.
Some people have allergic reactions. Some people see weakening of the immune system. Some people have trouble with liver and/or kidney function. I consider myself to be very fortunate not to have experienced those. I got very good results from chemo.
yes Chemotherapy is akin to snake oil. Although the efficacy varies greatly between patients and it may be effective for some patients for an extended period. If it’s not, then it’s on to the next one.
There’s always a solution.
Docetaxel effectiveness against bone mets
pluvicto + docetaxel 
Jevtana 
Finished upfront Docetaxel
Nubeqa or docetaxel and Liver Enzymes 
