The Hope of Immunotherapy

[Blackholes]

Interesting article on CAR T therapy for prostate bone metastasis.

miragenews.com/moffitt-scie...

[HopingForTheBest1]

I believe that the biggest issue with CAR T treatment is CRS, cytokine release syndrome, which has potentially serious side effects.

[dentaltwin in reply to HopingForTheBest1]

That is, of course, a big issue (similar to that seen in many covid cases) . Even so, there are stories like this one, from just a couple of days ago:

statnews.com/2023/05/03/emi...

[RMontana]

Thanks for sharing this...I was operated on and had sRT at Moffit; I live in the Tampa FL area...glad to see something publishes out of Moffitt...I read hundreds of medical articles and this is the first time I have seen something from Moffitt on PCa...the pull quote from this article is important;

“To our knowledge, this study is the first to evaluate gamma/delta T cells for expressing chimeric antigen receptor and treating bone metastatic prostate cancer. This strategy offers a dual-targeting mechanism to eradicate bone metastatic prostate cancer, a strategy that can be quickly translated to the clinical setting,” Abate-Daga said."

"The study was supported by the National Cancer Institute (P30CA07629, R01CA241169 and U01CA244101), Department of Defense Prostate Cancer Research Program (W81XWH-18-2-0013, W81XWH-18-2-0015, W81XWH-18-2-0016, W81XWH-18-2-0017, W81XWH-18-2-0018 and W81XWH-18-2-0019) and a team science award from Moffitt Cancer Center."

I cannot find the medical article but will keep looking...would like to see the type of study done...it appears we may be a ways away still from human trials...but baby steps...Rick