Psa doubling time: My husband's psa on... - Advanced Prostate...

Advanced Prostate Cancer

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Psa doubling time

Jerseygirl13 profile image
18 Replies

My husband's psa on 04/11/2023 was 3.16My husband's psa, 3 weeks later on 05/02/2023 is 6.21.

It has doubled in 3 weeks.

This is very concerning as it's been going down.

He is on a 6 month Eligard injection and zytiga + prednisone.

He had a psma pet scan last month which showed a spot outside his lung. Pelvic metastasis that were there on a previous CT scan shrunk by over 50%.

He has a CT scan scheduled on Memorial Day for the spot outside his lung.

Did not show on original scan.

Am I over reacting that the psa doubling time is concerning?

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Jerseygirl13 profile image
Jerseygirl13
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18 Replies
StayingSTRNG profile image
StayingSTRNG

Commenting because I am seeing similar with my dad in a similar timeframe. All the best to you and your husband!

Tall_Allen profile image
Tall_Allen

The scans are a better indicator than PSA. Maybe discuss switching from prednisone to dexamethasone.

LastMohikan profile image
LastMohikan in reply toTall_Allen

Daer TA, what will be the effect of switching from prednisone to dexamethasone? and at which conditions we need to take that action? thanks. Umit

Tall_Allen profile image
Tall_Allen in reply toLastMohikan

Rising PSA while taking abiraterone+prednisone while asymptomatic:

bjui-journals.onlinelibrary...

RMontana profile image
RMontana

I think I may have commented to you before, but to update my past remarks consider the following.

PSA doubling time (DT) is more important than PSA level. Keep an eye on this and if it works then PSA value is not as critical as the DT.

healthunlocked.com/active-s...

Also, sulforaphane has been clinically shown to slow down PSA rise, so consider a supplement or grow your own broccoli sprouts...I do both. Here are some good articles on this.

healthunlocked.com/active-s...

healthunlocked.com/active-s...

I currently use a Liposomine Sulforaphane from the UK, which has 150mg of the supplement listed…but you can use the pill and/ or grow sprouts.

healthunlocked.com/active-s...

Growing them is a bit of work, like having your own small farm in the kitchen…makes a great smoothie! YouTube has lots of good sites; here is one that seemed to work for me.

youtube.com/watch?v=U9iL8Kv...

Good luck...Rick

Bangkok profile image
Bangkok

No. Doubling time means everything. His Oncologist better be doing something consequential before he hits 20. 2 1/2 years ago (after 3 rounds of Lute-177 ) I had an 8 month reprieve of 0.041 then it started doubling again. I went back to Thailand had a PSMA pet scan then another round of Lute -177 then 20 rounds of IMRT. I have been holding steady at 0.01 for the last year. It's expensive but I wouldn't be here writing to you if it didn't work. I have had 18 months of Hormone treatments which was finished 3 months ago and no other treatment - I don't have a clue what all the acronyms mean that I read on this site. Good luck to you both.

Jerseygirl13 profile image
Jerseygirl13 in reply toBangkok

Hi there. So you had 4 rounds of lute-177 and 20 rounds of radiation? Where did they radiate? What hormone therapy were you on?

Bangkok profile image
Bangkok in reply toJerseygirl13

The IMRT was directed at my prostate. The Lute cleared up my Mets and there was a lot of them. The HT was Lupron but it's called Luproline in Thailand.

Teacherdude72 profile image
Teacherdude72

When I was, unintentionally, given a 6 month Eligard shot my psa doubled twice to 3.16 in less than three months. I choose monthly bloods testing. MO then gave me a 7.5mg Lupron shot. In one month reduced my psa to half of what the previous month was. Eventually added Nubeqa.

Tall_Allen profile image
Tall_Allen

Probably none of those affected his PSA much.

StayingSTRNG profile image
StayingSTRNG in reply toTall_Allen

any ideas of what could?

Tall_Allen profile image
Tall_Allen in reply toStayingSTRNG

Cancer

StayingSTRNG profile image
StayingSTRNG in reply toTall_Allen

alright, fair enough…

Boywonder56 profile image
Boywonder56 in reply toStayingSTRNG

Give the erleada time to work.....

elwoodpdowd profile image
elwoodpdowd

this is very serious and I urge you to contact the best cancer treatment center in your region. I live in the Pacific Northwest and entrust my cancer treatment to Swedish Medical Center and the University of Washington via the Fred Hutch Center (formerly Seattle Cancer Care Alliance). I had ten years from diagnosis (2011) to January of 2021, when my PSA jumped from 7.6 to 11.2, to research treatment options while on active surveillance. I chose SBRT (cyberknife) with Dr. Robert Meier at Swedish (the prostate cancer had spread to my ribs, sternum, and tailbone). I was on hormone therapy (ADT with Eligard) for two years. My PSA has remained undetectable for those two years and I no longer get quarterly Eligard shots. Your husband's doubling of his PSA is not a good sign. You need to find the closest top-notch treatment center (e.g. such as M.D. Anderson in Texas).

Seasid profile image
Seasid in reply toelwoodpdowd

On which ADT drug are you now?

elwoodpdowd profile image
elwoodpdowd in reply toSeasid

none. I was on hormone therapy for two years and my oncologist said let's see how you do without hormones. It's apparently common to suspend ADT and quarterly monitor PSA to see whether it becomes detectable. The theory being the SBRT destroyed all the metastasis (SBRT evidently scrambles the DNA of the cancer cells) shown on the body scan and two years of ADT effectively "starved" any lingering prostate cancer cells.

j-o-h-n profile image
j-o-h-n

Double means Trouble...................

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 05/05/2023 8:25 PM DST

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