Top 10 Best Sulforaphane Supplements: 24Apr23 Updated

[RMontana]

For those who are following my posts on the use of sulforaphane in the treatment of PCa, specifically its affects on PSA progression, I found a rating for the top 10 supplements that contain this compound. I dont know who this rating service is and some of the products shown dont actually contain stabilized sulforaphane...that I know of the only one in the world that does is from France and is the BROQ brand. Check out the top ten yourself; see 'Top10best.how/sulforaphane?'. I have taken this supplement for the last two years (see my other posts). I may now switch to Osasuma brand of Liposomal Sulforaphane.

Now, my 'go to' source for all things Sulforaphane is Rhanda Patrick Phd, and her round up of supplements with Dr Jed Fahey recommendations does not contain Osasuma's entry; neither does it list BROQ which is the landmark supplement source used in current phase 3 medical studies! So, I dont think in this case they have the entire ground covered, vis a vis best supplements available; see the podcast 'Which supplements are reliable sources of sulforaphane? | Jed Fahey' In the podcast Dr Fahey states we cannot get European supplements in the USA; he is wrong. I have been buying BROQ imported from France for 2 years plus...

I now find that there are other choices and the top 10 ratings led me to a new source that has 'Liposomal Sulforaphane.' OK, what is Liposomal Sulforaphane and how does it vary from 'stabilized' Sulforphane? There is a NIH publication that helps explain this and provides me some comfort to switch. Liposomal is not a different type of Sulforaphane, but a method of delivery and in the NIH publication references its explained in the abstract; it may help 'stabilize' the compound until you need it, which is after you swallow the gel cap. I confirmed with my brother, who has a Phd in natural products chemistry and who also works in the manufacture of vitamins in the USA, that 'Liposomal' is a method of protecting the nutrient during delivery. In his words; "A liposome is literally an artificial lipid bilayer sphere surrounding the active ingredient. It protects the active ingredient from reacting with surrounding chemicals and oxygen." So this all tracks; a 'Liposomated' nutrient should be equivalent to a 'stabilized' one.

NIH "Liposomes are delivery vehicles for transporting substances into the body effectively via facilitating absorption directly in the mouth or by preventing breakdown by stomach acid. Since the 1970s, liposomes have been investigated as potential drug delivery systems because of their biocompatibility and ability to incorporate both hydrophilic and hydrophobic therapeutic agents. Despite early promise, it was decades later, in the late 1990s to the present, that liposome technologies could create successful commercial products. Oral deliveries are recently emerging as availability of quality phospholipids and reliable homogenization and sizing equipment have become routinely available. Nutritional industry use of liposomes will grow rapidly in the next 5–10 y. High-quality products with more complex mixtures of pure compounds and complex botanical mixtures will offer clinicians less-invasive options for dosing and delivery of these actives." ncbi.nlm.nih.gov/pmc/articl...

Here are the listed advantages n disadvantages of Liposomal delivery; [comments in brackets are mine]

Advantages of Liposomal Delivery

High bioavailability and absorption compared with other oral forms of supplements [touted by the top rated brand as being why its 'better' than pure Sulforaphane supplements, like BROQ].

Noninvasive; avoids pain and discomfort associated with injections and decreases the contamination risk.

Micronized encapsulation protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.

Increased intracellular delivery [listed as both advantage n disadvantage].

Can hold both hydrophilic and hydrophobic compounds.

Ideal for those for whom swallowing a tablet is not possible.

Allow for adjustable and incremental dosing for children and adults.

Cost effective by being able to take a lower dose for the same effect.

Potential Disadvantages of Liposomal Delivery

High current cost. [not an issue; this publication was written in 2016]

Possibility of poor manufacturing eg, high particle size, poor ingredients [cant control this, but have some knowledge here. My brother is a Phd and works making vitamins n supplements…if they are sold in the USA there are some pretty robust rules and oversight on content. I cant go into these but if the label says its there you can expect that its true].

Possibility of instability [where 'stabilized' forms of the compound come in]

Increased intracellular delivery.

All things considered and since I am growing my own broccoli sprouts at home and consuming 100 g/ 2 cups a day, I will switch brands. The new top rated supplement is not only cheaper but now provides me a bit more than double the 60mg that was noted in the original and ongoing medical studies that I have already posted on this matter. Rick

PS Osasuna appears to be based in Switzerland...see here; moneyhouse.ch/en/company/os...

PSS I ordered and received my Liposomal Sulforaphane gel caps and they are manufactured by Osasuna in the UK...will proceed on this basis.

[Daddysgirl83]

We live in Sweden and nowhere can I order these brands Do you know where I might find them? Amazon says unavailable here.

[RMontana in reply to Daddysgirl83]

That is too bad. The BROQ Stabilized Sulforaphane comes from France. I don’t know why you could not sing it in the greater EU market. The Liposomal Stabilized Sulforaphane comes from the UK and is from a Swiss manufacturer. Again, why would you not be able to find it?

See my posts and let me know if you can’t see the bottles. I can repost images. Then take these and shop for them on line; they must be available to you. Let me know if you need the images of the bottles. Am traveling but can send best week

Plus don’t forget; you can grow broccoli sprouts. It’s easy and I suggest you do both supplements and sprouts.

there is some debate I see recently as to whether this supplement helps reduce PSA, because it reduces testosterone naturally, and therefore, is a type of natural hormone treatment. I don’t think this is correct. The studies that I saw, especially the one in France that made the supplement famous for treating prostate cancer, had patients that had testosterone levels of 4 ng/dL. This is nearly 0 and their PSA slowed down by 86%. So the supplement is not effective because it reduces testosterone. It must have some other action that makes it effective against prostate cancer.

…again let me know if you don’t have access to the images of the bottles. I will send those next week and you should be able to shop for them. They come from Europe so you should be able to get Thanks.

[RMontana in reply to Daddysgirl83]

...traveling I had no access to the bottles of supplements...here they are.

BROQ Sulforaphane, France source;

You should be able to find these in Europe...let me know...TNX

BROQ Supplement Bottle image

[RMontana in reply to Daddysgirl83]

...here is the most affordable option for a supplement...this is from the UK. I take it now. TNX

Image of Liposomal Sulforaphane supplement.

[Daddysgirl83 in reply to RMontana]

Thank you so much! I have searched everywhere and only place is Amazon and they are out of stock. 😞

[RMontana in reply to Daddysgirl83]

Wow...odd. If the supplements come from Europe, why cant they be found on the market? Odd. But can you buy the broccoli seeds and grow your own sprouts? I do this; its easy. You need only jars and a cabinet where they grow. 5 days with a good seed supplier will give you 10-12 days treatment. Each treatment is about 100 grams of sprouted seeds. You grow them for only 5 days, then freeze them in packs of 100 grams. Take them out each day, make a smoothie using other berries, and drink cold. I can send you more on this if you want. But grow your own sprouts if needed.

Here is the best on Amazon that I have found for the seeds; I have tried other brands but this is the best and worth the extra money. TNX

Image of broccoli sprout supplier

[Daddysgirl83 in reply to RMontana]

Yes really odd. Thank you alot! 🙏🏼 I will look into it!