my dad was xtandi and his psa went down - he was having issues so they took him
Off of it and then put him on 2 pills and just increased to 4 last month- now his psa went from .58 to 1.20 - he failed Zytiga after 2 years now this is not working what next? His dr recommended a pSMA scan if it goes up- are there other options
Chemotherapy, Provenge, Lu 177 PSMA, and eventually Xofigo
so there are alot of things left- also is chemo rough like it is with other cancers ?
While it is a variable side effect profile docetaxel is relatively well tolerated. I have completed 3 rounds last Wednesday and days 3-7 are usually where I have taste changes and nausea which are beginning to wane. Peripheral neuropathy is a common side effect so I ice my toes and fingers during the treatment. I lost my hair after dose one , some do some don’t even with ice cap. That’s what hats are for.😊 Just reporting my experience. Better than disease progression symptoms IMHO
Have you had any problems with bleeding while on Docetaxel? I will be getting 3rd dose this week, and among other issues, I have had rectal bleeding with bowel movements since dose one. I also seem to get bleeding ulcers in my nasal passages that start bleeding around day 6 after treatment..... luckily the nasal bleeding only lasts a few days . I think i get about all the side effects except for losing the fingernails....... guess there is always that to look forward to....
Gosh, no rectal bleeding. Minuscule nasal bleeding only noticed with dried mucous tissue, no frank blood
I am going to ask for a dose reduction starting with my 3rd dose to see if it helps with all the SEs....... It will go from 75mg/M2 to 60mg/m2........... should change it from a 160mg infusion to a 125mg infusion.....hoping its better tolerated, and enough of a dose that it still works
No one can give you an exact answer to that question. If you can, find other people (such as ones on this forum) and query their experiences.
also what is a pSMA scan - he already had Axumin and CT of everything
Some info about chemo:
accessdata.fda.gov/drugsatf...
grandroundsinurology.com/dr...
PSMA is a protein which is located on the surface and the inside of the prostate cells. It is highly expressed in PC cancer cells.
It is used for a target to molecules attached to radioactive metals.
The PSMA PET/CTs find these cells and identify where the cancer is located. They are the most sensitive scans to identify PC.
The molecules that target PSMA could also be attached to a more powerful and durable radioactive metal (Lu 177) and it is used as a treatment of the cancer with precise location and destruction of the cancer cells . The treatment is call Lu 177 PSMA 617 or Pluvicto.
Hi Chris, I've been through numerous treatments since I was diagnosed in February 2019 and provide the following:
Chemo - I've had 2 separate treatments of chemo. The first was Doxataxel from Feb 19 to June 19 for 6 sessions that I handled pretty well. Side effects were not significant. Second treatment was Cabizataxel for unlimited sessions from June 22 however I only lasted 5 sessions due to extreme side effects (fatigue, lack of taste & smell, poor sleep patterns, anxiety and others).
In between, I've had 2 tablet medications Enzalutamide (Xtandi) & Abiraterone (Zytiga). The first from June 20 to Nov 21. This medication worked well (reduced PSA from 6.30 to 1.90) but in Oct & Nov I started to suffer from memory loss (particularly recent) and my MO took me off it straight away & did say that memory loss can be a side effect of Xtandi. I only took Zytiga for about 5 months as it did not reduce my PSA at all.
I'm now about to start a treatment of Lutetium via the premier cancer hospital in Australia - Peter Mac here in Melbourne.
Please note that all treatments affect each & every patient differently. What I encountered as side effects may be vastly different for someone else.
Hope this, at least, helps a little. Happy to answer any questions you might have. Best wishes to you & your family on this roller-coaster.
thank you. I just get so discouraged and worried- I just hope there are a lot of txs out there and that something will work- I hope and pray you will find success too!
Chris, positivity is one of the keys to the support from family and friends. The mountain of information that is available on PC is certainly overwhelming but helps the sufferer, family and friends to understand PC and also what treatment is available.
I don't know where you reside but here in Australia we have groups in many towns / regions called Prostate Cancer Support Group. This allows men & their partners to meet up locally on a regular basis with others to talk about this. A great help & comfort.
I am in US - Pennsylvania
What issue did he Have on zandi
so far nothing just that psa went from .6 to 1.2
what is his age?
80 but he is in great shape thank God 
Chris you have been with us for at least 3 years, would you be kind enough to give us more detail regarding your dear Dad. Age, Location, Health etc. (all info voluntary). And it would be best to be in his bio..... Thanks....
Good Luck, Good Health and Good Humor.
j-o-h-n Tuesday 02/28/2023 3:36 PM EST
80 from PA
I am no doctor but, if the PSMA scan shows isolated Mets you might investigate spot radiation.
PSMA PET/CT scans only show places that express PSMA, and are not necessarily PCa spots. My MO said my spots were possibly PCa but without biopsy to confirm could not be sure.
Re your dad's returning PCa after abiraterone, you might look up trials where Darolutamide instead can continue to suppress PCa. Daro is expensive. Switching back and forth over time can re-activate hormone sensitivity. Radiation merely based on a PSMA PET/CT scan is probably not going to get approved by insurance.
my dad is metastatic though is that indicated for metastatic or just non
Xtandi failed awaiting new therapy
Help Me Help Dad- Xtandi Fail
Has anyone experienced a significant decrease in PSA on Zytiga and then an increase 
Xtandi vs Orgovyx
