boron and prostate cancer

[Radars]

I have locally advanced prostate cancer finished treatment 2016,I now have osteoporosis, does anyone know if boron is safe.

[Tall_Allen]

Borax/boric acid is only slightly toxic, but is a good water softener and good for ant and roach control.

[Radars in reply to Tall_Allen]

hi,I have got locally advanced prostate cancer, finished treatment 2016,and now I have got severe osteoporosis, I have just purchased 3mg boron for my bones is it ok for PC,I will soon having zoledronic infusion, I have been reading on canceractive that bisphosphonates makes brittle bones worse.

[Tall_Allen in reply to Radars]

Zometa and Xgeva have been proven to prevent fractures and spinal compression.

While small amounts of boron are needed for healthy bones, that doesn't mean that more is better. It is only needed in trace amounts, and food sources are always absorbed better than pills. Good sources include: avocados, red kidney beans, lentils, prunes, red wine, hazel nuts, raisins, peaches, dried apricots, red grapes, and almonds.

Don't take any unprescribed supplements for osteoporosis, and certainly not without telling your doctor. Calcium, for example, may be harmful, and Vitamin D may pull calcium out of bones. Get serum tests first.

[Radars in reply to Tall_Allen]

my gp has sent me a prescription for adcal,don't know whether to take it or not, I have been taking a ppi for years, and I have read a lot that they stop your body from absorbing calcium and nutrients, k2 mk-7 puts calcium into your bones,and I take 1000iu vit d the reason I have osteoporosis is because my testosterone has not recovered.

[Tall_Allen in reply to Radars]

So you take one supplement to counteract another? It sounds like you are going down a black hole. Here's what happens to your bones when you megadose Vitamin D:

jamanetwork.com/journals/ja...

I suggest you listen to your oncologist instead of Dr Google or a gp who is not a specialist.

[Radars in reply to Tall_Allen]

what are you on about megadosing I take 1000iu d3 with k2 mk-7 I am not in touch with oncologist, and I have to take a ppi for hiatus hernia regarding gps they all say different things about the same problem, listening to gps via phone calls is ridiculous.

[Tall_Allen in reply to Radars]

If you read the study I linked, you will see that 1000iu Vitamin D is a megadose. It only requires supplementation if your serum levels are low. This shows what our current best info about Vitamin D is:

prostatecancer.news/2018/07...

If you have advanced prostate cancer, why aren't you seeing an oncologist? If you've been cured, why are you taking supplements? Those who think they know better than oncologists are almost 3 times as likely to die of cancer.

[Radars in reply to Tall_Allen]

10,000 is a megadose and some people require more than others,1000iu is ok.why should I see my oncologist he did my rt/ht then I was released to urology, then I was put on intermittent ht,and referred to my gp and 6 monthly checks, psa 0.05,but testosterone not recovered, hence osteoporosis, I have asked for some testosterone but no.

[Tall_Allen in reply to Radars]

10,000 is a megadose, but so is 1,000. The current RDA is 600 iu/day from all sources (including sunlight). Only for people who are deficient, 400 iu is recommended as a supplement.

hgov.uk/government/publicati...

It sounds like you've already had curative therapy (when you get a chance, it helps to add this info to your profile). I'm sorry that your doctor won't prescribe TRT. Sometimes HCG or clomid can kick-start your natural testosterone production.

[Radars in reply to Tall_Allen]

yeah thanks, I will reduce my vit d,I won't take the adcal lemon chews full of sugar, I am having a blood test tomorrow, blood profile &vit d,then on 7th Feb appointment with endocrinologist, prior to starting zoledronic acid infusion, but before then dental work, regarding testosterone a guy from hull same diagnosis as me has testosterone every 3months,(bat therapy)he's doing OK,and he was Gleason 9,and I'm Gleason 7,locally advanced.

[dentaltwin in reply to Tall_Allen]

My absorption must suck; I take 2,000 IU/day and I'm just barely above deficient. Everyone is different, of course.

[Radars in reply to Tall_Allen]

been for a blood test today at the hospital, just received a text from gp to say my vit d level is ok,but never mentioned anything else ie my calcium levels or anything, except take the adcal on its own without any other vit d supplements,

[Tall_Allen in reply to Radars]

Blood tests usually have calcium levels.

[Radars in reply to Tall_Allen]

calcium levels 2.37(corrected 2.35)which is normal range 2.2 to 2.6)vit d normal 65.,she said if I don't wish to take adcal continue with vit d3 400-800iu,I have been referred urgent to endocrine team for zoledronic infusion, so the lansoprazole 30mgs isn't stopping me from absorbing calcium, so that's not bad.

[Tall_Allen in reply to Radars]

In a randomized clinical trial, combining Zometa with Celebrex lengthened survival by 22%. "Preplanned subgroup analyses in men with metastatic disease showed a hazard ratio of 0.78 (95% CI, 0.62 to 0.98; P = .033) for SOC + ZA + Cel."

ascopubs.org/doi/10.1200/JC...

Neither Zometa alone or Celebrex alone had any effect on survival. You may want to discuss getting both.

[SeosamhM in reply to Tall_Allen]

Finally, some advice I can put to use!

[spencoid2 in reply to Tall_Allen]

also great for wood boring beetles. i still have 127 ounces out of the gallon i bought in case anyone wants some. i do not recommend it for internal consumption or even external application other than on bugs you want to kill, i think i'll get my boron from peaches and avocados

[TwilightZone]

They have me on 1000 units calcium, daily. AND, receive 60 mg. injection of PROLIA every six months.

[Radars]

I am having a blood test today for bone profile and vit d

[Graham49 in reply to Radars]

Vitamin D deficiency aggravates growth and metastasis of prostate cancer through promoting EMT in two β-catenin-related mechanismsZhi-Hui Zhang, Ming-Dong Liu, Kai Yao, Shen Xu, De-Xin Yu, Dong-Dong Xie, De-Xiang Xu

The Journal of Nutritional Biochemistry 111, 109177, 2023

Increasing evidence has demonstrated that vitamin D deficiency is associated with prostate cancer progression, but its mechanism remains unclear. This study investigated effects of vitamin D deficiency on growth and metastasis of prostate cancer. Nude mice and Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice were fed with vitamin D-deficient (VDD) diets. Prostate cancer growth was aggravated in VDD diet-fed nude mice and TRAMP mice. Invasion and metastasis of prostate cancer were exacerbated in VDD diet-fed TRAMP mice. In vitro experiments showed that calcitriol, an active vitamin D3, inhibited migration and invasion in transforming growth factor (TGF)-β1 -stimulated and -unstimulated PC-3 and DU145 cells. Mechanistically, calcitriol inhibited epithelial-mesenchymal transition (EMT) in TGF-β1 -stimulated and -unstimulated DU145 cells. Unexpectedly, calcitriol did not inhibit Smad2/3 phosphorylation in TGF-β1-stimulated DU145 cells. Instead, calcitriol downregulated expression of proliferation-, metastasis- and EMT-related genes, includes Cyclin D1, MMP7, and Zeb1, by inhibiting interaction between TCF4 and β-catenin. In addition, calcitriol promoted interaction between cytoplasmic VDR and β-catenin, reduced β-catenin phosphorylation and elevated β-catenin/E-cadherin adherens junction complex formation. We provide novel evidence that vitamin D deficiency aggravates growth and metastasis of prostate cancer possibly through promoting EMT in two β-catenin-related mechanisms.

[NecessarilySo]

I'm on Prolia every 6 months and take 5000 Vit D3/day. Blood level of D increased slightly, 29 to 32. My Osteoporosis recently dropped to Ostopenia. T-score was -2.6, now -2.3.

[Radars in reply to NecessarilySo]

that's good I have been taking 1000iu d3 and k2 mk-7, tall Allen says my 1000iu is megadose.i have had a blood test today to see whats what, I will be starting zoledronic acid infusion after dental work.

[London441]

I don’t understand megadosing vitamin D without first checking for deficiency and I don’t want to understand it. It’s typical to supplement blindly like this unfortunately. Plenty of supplements don’t do what they are claimed to do but megadoses have no consequences, so at least then one is just wasting money. Vitamin D isn’t one of them. Glad you are getting tested for it.

How much do you exercise, how often and what kind?

[Radars in reply to London441]

I used to do weight training, but now with severe osteoporosis I've had to stop,I go for a walk everyday, I am having zoledronic acid soon after dental work.

[London441 in reply to Radars]

You can always work your way back to the weight training with calisthenics. Keep an open mind. To abandon it entirely and depend on supplements and bone strengthening drugs alone won’t work unless you’re walking a lot. Rucking (walking with a weighted vest or pack) is good also, but you still need upper body strength.

Don’t give in. Nothing is more regrettable than allowing yourself to weaken further.

[No_stone_unturned]

I’ve been taking 3mg of boron a day for about a year along with many other supplements. I can’t really testify to any concrete benefits other than feeling relatively good. I stay the course with supplements mostly because I feel like I have nothing to lose (but $) which is fine for me. Perhaps it’s placebo, but it gives me a sense of control, as if I’m doing something instead of sitting around waiting to die. It’s because of this reason , why you’ll never hear me poo poo anyone using supplements. If it works for you and you’re not causing any harm to yourself or others… go for it! That’s my philosophy.

On the upside; like I mentioned, I do feel more in balance and my metabolism seems to be more consistent. I’ve avoided Covid with it all around me, I seem to fair better with common cold and the like than other ppl in my house. Although my PSA is rising my scans show no progression and my AP is 85. Is it because of the supplements, mushrooms and fenbendazole? I have no idea, no one does. But until I run out of money or I’ve become convinced that it has no benefit at all, I’ll stay the course.

Good luck radar!

Best

D

[dhccpa]

I've taken 3-6 mg of boron for well over 2.5 years now. I haven't seen any negative effects.

Regarding Vitamin D, many doctors (not necessarily oncologist) still seem enamored of supplementing it. I don't know why, as I do understand being in the normal range. But there does seem to be somewhat of a division of opinion on how much is needed.

[pd63]

30 years ago my dad thought taking a teaspoon of sunflower weeds/day would sort his urinary problems out, he'd been to a healthfood shop for advice, brown rice and wacky baccy brigade probably.A year later was admitted as emergency due to urinary retention turned out to be advanced pc.

I wouldn't touch anything without a doctor's advice, toomany witchdoctors out there

[Radars in reply to pd63]

certain things yeah,

[gsun]

I take 400 IU a day. I had MS (in remission) and my neuro said to take this for brain health.

[Hidden in reply to gsun]

Bravo gsun! 👍

[gsun in reply to gsun]

I meant 4000IU a day

[Hidden in reply to gsun]

I take 1000i.u. a day. No way is that mega-dosing. My wife takes the same dose and it was recommended by her Mayo doctor.

[gsun in reply to Hidden]

No, it’s not.

[Hidden]

My Nat onco put me on a complex with boron . I read a lot about it years ago . I was even thinking about eating some boraxo back then . K-2 , d-3 , boron , magnesium .a little calcium , not too much .and im probably the only one here also taking strontium for osteopenia .This is basically a standard of care cite now . There isn’t a lot of belief here by most in extra nutrition . I am one of the odd balls . My plan has left me undetectable for seven years now .. we are told apc always returns. I’ll do anything to delay that . Good luck Radars ..

[Radars]

yeah thanks I know you can't win with no testosterone, I was diagnosed in 2014,t3b no mo,I finished treatment in 2016,I know I have done well, but also I knew I would have other problems hence osteoporosis, I have asked for trt and be monitored but no,zoledronic acid is my best bet now.

[BigglesOz]

Never mind Tall Allen - he hasn’t a clue about Boron.

A Walter Last ran the story about Boron and its effectiveness for arthritis and bone loss and the anti cancer properties. Search ‘walter last boron’. The piece has been reprinted in other websites… and it’s a good read and has dosage info.

Of particular interest is the comment that B can increase T production… not desirable with PCa. Mercola has run a similar piece on the B story. Search for WLs article, educate yourself and be more empowered to decide rather than taking the opinions of those who parrot.

All good and keep plugging away at it. As my GP told me once ‘The only way to defeat cancer is to know more than your Oncologist.’

[Radars in reply to BigglesOz]

thanks just taking 3mg to help with bones along with 1000iu d3 k2 mk-7 if it increases testosterone ok,but I can't lift weights now with severe osteoporosis, waiting for zoledronic acid.

[Radars in reply to BigglesOz]

thanks, different opinions regarding boron it is ok for PC,it's megadoses that's dodgy.

[Hidden]

Can you spell out that site URL for me? I couldn't find that site.

[Bacana]

Knowing that testosterone always wins, are you in favor of Zometa as a treatment for osteoporosis?

[Radars in reply to Bacana]

I am going to have zoledronic acid

[Radars in reply to Radars]

I will be having zoledronic acid or denosumab what else can I do with my dx.

[Radars]

do you think prolia is better than zoledronic acid and why

[Radars]

yeah, I think I will be starting zoledronic acid first, most people say that's the way to go