Revolutionary gene therapy offers hope for untreatable cancers

[cesces]

This is pretty fundamental

Seems like there should be no reason this would not work with prostate cancer

Revolutionary gene therapy offers hope for untreatable cancers | Cancer research | The Guardian

Https://theguardian.com/science/202...

But recent progress in cell therapy offered a new method for tackling her condition. T-cells were collected from a healthy donor and changed so that they could kill other T-cells, including her leukaemia cells. This was done using base editing, which allows scientists to make a single change in the billions of letters of DNA that make up a person’s genetic code.

Other technologies can achieve such minute changes, but are associated with more side effects. This is less of a problem with base editing and allowed the Gosh team to make a series of separate changes to the donated T-cells. These complex alterations were needed to ensure the realigned T-cells only attacked leukaemic T-cells and did not destroy each other through “friendly fire”. They also allowed the cells to work after chemotherapy and also prevented them from affecting normal cells.

The crucial point is that Alyssa’s therapy was based on donated T-cells which can be edited, so donor-matching is not a problem. “This is an ‘off the shelf’ universal cell therapy and – if replicated – will mark a huge step forward in these types of treatments,” said Dr Louise Jones of the Medical Research Council, which funded the project.

[Scout4answers]

A cure is coming…