Started Nubequa a month ago and experienced soreness throughout……….legs, back, shoulders. Just started reducing dosage to 2 pills in am but only 1 in the evening. Contine with 1 Orgovyx pill in am. PSA test this week continues to show slow drop from 18 to 16…….seven slow drops in a row prior from 7 Docetaxel cycles in 2022, down from 56 to 18. . Last chemo infusion was September 29, first Nubequa was November 8.
Anybody else experience this with Nubequa?
mike
I started orgovyx in July after a 2 year break from ADT. Orgovyx gives me mild hot flashes and some weakness, but it is very effective at lowering T to zero. My doctor added Erleada in October, and after increasing joint pain and a horrible metallic taste in my mouth, he switched me to Nubeqa in November. The taste is fading, but the joint pain is significant and increasing. Besides having a long history of back pain, now my shoulders and hips have joined the pain club, making it difficult to reach out to pick up stuff. In support of the theory that exercise is beneficial, I am in a geezer fitness group at a local Crossfit place, and one hour of vigorous workout really does help. To be able to press through that hour is a struggle, but well worth it. I still question the use of Nubeqa in my case (RP in 2015, SBRT to one spine met this year, with other history in my profile) but my doctor is convinced that this is the right approach.
Thanks for the feedback. I accept that no testosterone from Orgovyx makes you weak but the overall soreness is what I wanted to hear about from other Nubequa users. 13 cycles of chemo over 1.5 years in 2021-2022 never made me this sore.
Mike
It is the Nubeqa that has increased my joint pain.
Been On 1200mg. per day NUBEQA since July 29, 2022. I'm doing great with no pain and very little fatigue. I workout every other day: walk 2 miles, plus 25-30 minutes of resistance training on my TotalGym XLS. Have stage 4 prostate cancer, which has for now stopped spreading, PSA down to 0.30. I'm 72 years old and regularly get injections of Prolia and Eligard. Hope this inspires you. Good luck!
Great news….did you ever consider or need to take chemo?
I'm 7 years into my journey and doctor has mentioned chemo as a possible future treatment option.
Come to think of it, NUBEQA is considered a form of chemo...........so I've been told by my doctor.
also on full dose orgoveyx and Nubeua. Work around the pain on my total gym, stretching and walks controlling the pc for 23yrs, turned 84 yrs old past nov,
I was on full dose Nubeqa for over year and a half until it stopped working while also receiving Lupron injections every three months and I did see a small increase in both joint and muscle pain but most of my symptoms were from the castrate effects of the Lupron. In spite of the pain and discomfort I continue to workout daily. I do believe the meds have accelerated my pre-existing osteoarthritis but I have no real proof of that. One disturbing side effect of the darolutamide that I had was constipation. Stay hydrated my friend.
Experienced significant joint pain from Firmagon/Lupron early in treatment. Attributed it to accelerated arthritis from zero testosterone. Resolved almost completely with first ADT vacation and vigorous exercise. Now on full dose Nubeqa mono therapy and have no similar Side effects or pain. Orgovix and no T might be the cause of your joint pain.
Celecoxib May be worth considering for joint pains, whether due to Nubeqa SE or from osteoarthritis. May also beneficial for PC progression. I take 2 X 200mg /day.
Husband (age 76) has been on Nubeqa for over 2 years. Fewer issues than Xtandi. Haven’t heard him say fatigue is any worse. He’s almost 10 years into this journey.
I switched from Zytega to Nubeqa in June. Also get 3 month Eligard shots. Did 6 cycles of Docetaxel which started in July and ended at the end of October. No issues with muscle aches. Only issues I’ve had are associated with no testosterone as well as fatigue and hair loss from the chemo. Chemo fatigue only lasted the week after my infusion.
Been on Nubeqa 20 months. Monthly Lupron, my choice. Literally no pains other than my Dupuytrens after weight training. Energy low but hit the gym 5 days a week. G9 Fall of 2015 Radiation/lipron. More just ask.
Thanks for the information……..cutting back to 3 pills a day.
Mike
If Dr suggested Go for it. Suggest you check your T and psa monthly to be on the safe side. Wishing you the best.
Thanks and good health to you. My doc has never had a patient on Nubequa…….I went through Bayer to get it…..he wants to see how I do as mCRPC metastatic guy who isn’t a hormone sensitive patient.
Mike
Single digit decimals, it just got real
Is it reasonable to pursue ultrasensitive PSA test that is more precise than undetectable at <0.05?
My 22 month psa after radiation treatment (SBRT) is 1.25. What should my nadir be? Less than 0.5?
Lupron Shot - Numbness in Quads Muscles
Rechallenge with Xtandi 
