My 22 month psa after radiation treatment (SBRT) is 1.25. What should my nadir be? Less than 0.5?

[mike2344]

I just had my PSA test today (8/21/20) and the number is 1.25 as compared to 1.69 on 3/19/20. I was diagnosed with PC in July 2018 with Greason score of 7 (4 + 3). I had radiation treatment (SBRT) at UCLA in October 2018.

I have enclosed my historical PSA from 2012. Please note that I had a couple of PSA Bounces from 10/19/19 to 2/18/20. I am guessing that my PSA Bounce was caused by prostatitis which seemed to go away after I took Antibiotic in June'20.

PSA 3/19/20 (1.69), 2/18/20 (`1.84), 2/3/20 (2.46), 1/28/20 (4.06),11/26/19 (1.68), 10/19/19 (2.03), 7/19/19 (1.91), 4/16/19 (2.58), 1/21/19 (3.8), 8/29/18 (7.84), 7/9/18 ( 7.82) 5/15/18 (7.15) 10/16/17 (6.07) 3/3/15 (4.06) 9/24/14 (4.69) 10/18/13 (3.79) 3/22/12 (3.97),

mail.google.com/mail/u/0/?t...

Should I be concerned about my psa has not gone under 1 after almost 2 years?

Mike

[LearnAll]

Mike,

PSA Nadir is a graded parameter ...there is no fixed point at which it can be called good or bad. General rule is "lower the better"

In your case, the prostatitis may be causing confusion as even after treatment with antibiotics , there may be residual infection contributing a little to your overall PSA.

One should not depend on PSA alone when assessing effectiveness of treatments. Other biomarkers such as ALP, CRP, LDH, Albumin, Hb%, NL Rati, PL Ratio and LM Ratio should be checked and put together to get a composite picture and that can give a more accurate conclusion. Also, ability to tolerate physical exercise and overall general health should be also taken into consideration. A Nadir of 1.25 is not bad, if it was above 4.0 ,I would be concerned. Best wishes.

[mike2344 in reply to LearnAll]

Thanks for your response. Mike

[Hidden]

Its still going down....

[mike2344 in reply to Hidden]

Thanks for your response. Mike

[Gearhead]

Mike,

Looking at this and your prior posts, it's not clear if you do or don't have any metastecies. Can you please address that, at least to the best of your understanding?

[mike2344 in reply to Gearhead]

Thanks for your response. I don't think I have any metastecies yet. Mike

[Tall_Allen]

It took me 4 years to reach my nadir.

BTW- you do not seem to have advanced PC. You may get more relevant responses by posting on the following forum:

healthunlocked.com/prostate...

[mike2344 in reply to Tall_Allen]

Thanks for your response. I will post on another site you sent. Mike

[j-o-h-n]

If issues, come back....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 08/23/2020 12:40 PM DST

[monte1111]

Hope you don't have to come back here. Best of wishes.

[Abiathar]

It took me 8 years to reach nadir. It is way too soon to be concerned. Your numbers look good.