Cancel Care Oncology Protocol

[DeLeMere]

The C.O.C. protocol

.The 4 prescription drugs

Metformin,

Avostatin,

Doxycycline,

Membenazole

Is anyone here on them?

[novatimo]

In addition to some standard of care (radiation, ADT), I've been on the CO Protocol for the past 4 years.

[DeLeMere in reply to novatimo]

I happened to see your reply, “I'm on the Care Oncology protocol (Metformin, Atorvastatin, Mebendazole, Doxycycline), plus Modified Citrus Pectin, 81mg aspirin, and other supplements to inhibit angiogenesis and promote apoptosis.]”

WhT is the modified citrus pectin? What is it for? And was it suggested by COC?

Did you take anything else?

[novatimo in reply to DeLeMere]

I was taking modified citrus pectin long before going on the COC. Although the makers do not tout this aspect of MCP, I understand that it tends to makes the inside of the blood vessels "slippery" (either physically or biochemically) so that circulating tumor cells (CTC) have more difficulty finding a place to attach and grow into a tumor. I also take 81mg aspirin (3x/week) which tends to thin the blood, again making it more difficult for CTCs to clump and form new tumor sites. I started the MCP and aspirin shortly after being diagnosed in 2012 with Gleason 9 (4+5) and Stage 4 (though no visible metastasis). Have also done intermittent ADT over the past 10 years, currently on Xtandi (monotherapy) as all other forms and protocols involving ADT caused intolerable night sweats that disrupted sleep and seriously affected QofL.

[lcfcpolo]

I'm using the Care Oncology Clinic. It's difficult to say for sure if the protocol does anything as I'm also on Enzalutamide and quarterly PROSTAP ADT.

However, with so much discussion around statins and Metformin, particularly if taken together, I will continue to take the protocol. They are easy to tolerate so far. I think Doxycycline is unlikely to be beneficial but to be honest, who knows.

That's fundamentally the thing with Care Oncology, there are no studies or data for Advanced Prostate Cancer but it might help, so why not.

Good luck and please ask if any other questions.

[DeLeMere in reply to lcfcpolo]

Do they take insurance?

[lcfcpolo in reply to DeLeMere]

I'm in the UK. This is self pay here.

I guess you could try your medical oncologist or GP to see if they will prescribe any of the repurposed drugs.

Otherwise call Care Oncology. They have a website and phone number for the USA. My guess is that like the UK, it is self pay though.

[MateoBeach]

Part of the theory behind COC choosing these is to reduce inflammation. Atorvastatin has anti-inflammatory properties as well as LDL-cholesterol benefits for many.

Doxycycline has well known anti-inflammatory effects. However, it has strongly adverse effects on the gut microbiome, as do most antibiotics. So I won’t use it. Better choice for that would be celecoxib and/or low dose enteric aspirin, if one has a good stomach for it. Then multiple of our favorite photochemical supplements also. (Including Curcumin, Fisetin, Quercetin, Sulforaphane, ECGC and others).

Metformin has some benefits on metabolic pathways, but no demonstrable benefits seen on PC.

[Daveofnj in reply to MateoBeach]

I raised that question about the effect of doxy on gut microbiome with my physician. He said he thinks at the dosage levels prescribed by COC it would have little effect. Just his opinion.

[MateoBeach in reply to Daveofnj]

it is very easy to search, even on google, rather than a guess. The following link is one of many. Bifidobacteria reduction is a concern because it is one of the most important groups for healthy gut functions.

bmjopen.bmj.com/content/10/...

[Daveofnj in reply to MateoBeach]

Thanks. What my M.D. is saying is the effect is dose dependent. I've read others say the same thing, but I have no stake in being correct.

[KocoPr]

it is self pay in USA, but not expensive.

They have their own special pharmacy that fills your prescriptions and you also need to work with your regular OC and let them know of the prescriptions. There is research on all if those drugs with respect to prostate cancer but NO RCT trials.

I tried it for short period of time but I didn’t like pumping doxy, (bad for gut health), metformin (bad upset stomach), Atorvastatin not great for heart health as it lowers the so called bad cholesterol LDL which 80% is made up of the good “large cholesterol molecules, membendazole is an anthilmentic but it also interrupts the microtubule formation during cell mitosis which is a good thing if you have a DNA damage repair gene mutation/s.

I ended up going with Orgovyx and Darolutamide along with SARMs and a bunch of natural supplements that I either wild harvest and or buy in bulk and either encapsulate or make alcohol or DMSO extractions.

Example: i buy nano particles of quercitin, Andrograhis, sylamarin, curcumin, berberine, ginger, frankincense, egcg,

I also wild harvest the berberine and jap knotweed and make alcohol tinctures, and wild harvest many different mushrooms and make water extractions.

To replace membendazole or fenbendazole i wild harvest black walnut (spring buds/ leaflets or fall green husks and extract with dmso then i take 20 drops of that mixed with any or several nano powders, and 10 drops of distilled water (never take dmso without cutting it with distilled water) , also any mixture with dmso MUST be pure 100% no additives or fillers.

Im sorry for rambling on just wanted to give you some options and things to research.

Research research research

John

[Hidden]

Partially on this protocol I suppose. Metformin, atorvastatin, MCP, and IP6&Inositol.

[KocoPr in reply to Hidden]

thanks for that IP6 info

It is an amazing phytochemical phytic acid

ncbi.nlm.nih.gov/pmc/articl...

Now to look up inositol which I know it is naturally abundant in Jerusalem artichokes and burdock root. I did read up on inositol and prostate cancer but i need to re-investigate. Lol so many rabbit holes

[Purple-Bike in reply to KocoPr]

Impressive for IP6, but on mice. Is there anything to be found on humans?

[KocoPr in reply to Purple-Bike]

i find that it is rear to find human trials on specific phytonutrients unless it is a diet like Mediterranean or keto.

[KocoPr in reply to Hidden]

do you have a brand and quantity that you recommend

[Hidden in reply to KocoPr]

I get Nature's Way (Cell Forte) IP-6 & Inositol from Vitacost. 240 Vegan capsules. Says IP-6 800mg; Inositol 220 mg. Good luck on your journey with this disease.

[donits]

Hi, I had biochemical relapse and was taking bicalutamide 140mg. PSA level was slowly rising but still below 1. Then, as part of a clinical trial, I started taking atorvastatin. PSA continued to rise, but even more slowly. Then I found info on the web about test on mice that were given atorvastatin and metformin. Tests have shown that this combination destroys prostate cancer cells. I started taking metformin 1500mg a day and over time my psa dropped from 0.94 to 0.64. I know patients from another forum who take, in addition to hormone therapy intravenous infusions of doxycycline, turmeric and other substances. They are still alive despite advanced cancer and high Gleason.

Greeting to all

[donits in reply to donits]

I apologize for the mistakes: Bicalutamide 150mg, Atorvastatin 80mg.

[Wings-of-Eagles]

Metaformins effects on PC are negligible.

[donits in reply to Wings-of-Eagles]

You are absolutely right. Metformin taken alone does not do much, as do many other drugs alone. But when taken 1500mg together with atorvastatin 80mg, it has effects in biochemical relapses, at least for me. Turmeric also has a negligible effect because the body absorbs a small amount, but when taken as an intravenous infusion + standard treatment, it already gives better results. Each cancer is different and different medicines may or may not work for each patient. But you have to fight.