CDK12 mutation

[JolleySprings]

We have had Foundation One test and Gradient Blood biopsy which both report CDK12 mutation.

There is no “definitive” SOC for this rare mutation.

We are in yr 5 since RP surgery, radiation, and two rounds of Lupron/Casodex.

The Lupron/Casodex has stopped working. PSA went from .9 to 2.9 in 6 months.

He had a PSMA scan two weeks ago … and it came back as “clear” of any activity. No change since PSMA scan in September of 2020.

With his PSA being 2.9 I would think something would have shown up on PSMA scan.

Dr. Antonarakas is suggesting Nebuqa (sp?) with Casodex as next line of treatment.

Any thoughts?

Thank you!

[JolleySprings]

please! Thank you!

[Tall_Allen]

The Magnitude Trial showed effectiveness of Zytiga+PARP inhibitor in patients who are CDK12+:

prostatecancer.news/2022/06...

Other clinical trials worth considering are linked in my response on this thread:

healthunlocked.com/advanced...

Not all tumors express PSMA. Discuss the following trial with Antonarakis. It suggests that a triplet therapy of Nubeqa+ADT+chemo may get superior results. The trial used Xtandi but it would probably work with Nubeqa too:

prostatecancer.news/2022/10...

[JolleySprings in reply to Tall_Allen]

Thank you so much!!!