I read as much as I could find on the CDK12 mutation but have not made any real progress in determining exactly what it means that I have this mutation. I had both biopsy and germline genetic testing. I thought that no mutations were found because it had been a while and I am pretty sure that is what was said? However I just found out that I do have the CDK12 mutation and am trying to figure out exactly what that implies. I understand that it can help in choosing therapies that might be more effective instead of picking them randomly. So I guess this is good because choosing future treatment if necessary (other than ADT) might be made easier.
What treatments are currently available that target this mutation? Are they in trials or are there approved or other treatments?
Dr. Aggerwall suggested that pursuing the 177Lu-PSMA treatment will be a major challenge and that he did not think there was not enough benefit to justify the effort.
So I guess my best bet might be immunotherapy targeting the CDK12 mutation?
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i looked on clinicaltrials.gov and did not find much of anything? Should i just stick with ADT as long as i am CS and not worry about trials until i become CR or someone does a trial for CS MPC
i find one study searching for palbociclib. They are only recruiting in Connecticut, not convenient. nothing for the other two. should i be concerned and looking for this sort of study or just wait until CR or ??? clinicaltrials.gov not.com
Even if you don't qualify, call them anyway. They may have something coming up soon that they haven't listed, or they may be able to get you on an active trial that they are not recruiting for.
There is someone on this forum who has the CDK 12 mutation who is responding well to Keytruda. He was on a parp inhibitor (Olaparib I believe) that didn’t work. He just recently switched to Keytruda. Look up Manomar
My boyfriend's oncologist at MD Anderson said the same thing. He has failed on everything else except x Zytiga which gave him 22 months pain free and x the duration of tx, his tumors shrinked.
i really know nothing about it. i just had the genetic test and this is the only thing that showed up that they were looking for. i would like to know more. i did not think of it as a problem just informatin that could help decide on treatment. you have me thinking i should check it out. please share anything you know. i just finished 10 rounds of chemo after becoming castrate resistant.
i did will get another appointment with onco asap wonder why they bothered with 10 treatments of doxytaxel i got the results of the genetic test at one point and it said nothing they were tracing was found. then months or even more later i got a notice about cdk12 and that is when i wrote to this forum maybe onco was not notified because it should have affected treatment.
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