Eligibility for Lu-177

[Loveudad]

My father has metastatic prostate cancer with gleason score 9. He was diagnosed 2years back. He has already received docetaxel abiraterone and cabazitaxel. But his disease keeps relapsing.

Doctors asked for the test NGS with Brca. His test results results are negative.

is this test mandatory mandatory for lu-177 ??

My father is suffering from severe pain. I really pray he gets the new treatment.

[GP24]

A BRCA test is not required for Lu177 but it is reasonable to check it. Get the Lu177 treatment. It may cause a pain flare in the beginning though.

[Tall_Allen]

The major requirements for Pluvicto in the US are tried chemo, tried a 2nd gen hormonal (like abiraterone), high PSMA avidity on a PSMA PET scan, and adequate organ function and blood work. So he sounds like a good candidate. I also think an FDG PET scan is prudent in heavily treated men like him.

[lokibear0803 in reply to Tall_Allen]

Hi TA — does this mean that one need not have mets visible on conventional imaging? or is it that mets must be visible on MRI, CT or bone scan but must also be PSMA-positive? Many thanks —

[Tall_Allen in reply to lokibear0803]

There is a requirement for mCRPC, which always means on conventional imaging.

[chrisrock]

No, NGS with BRCA is not mandatory for Lu-177. However if BRCA is found to be positive, then there are better chances of response to Lu-177 therapy.