Estetrol Prevents Hot Flushes and Improves Quality of Life in Patients with Advanced Prostate Cancer on ADT

[PJ95]

Interesting or maybe even promising .....

sciencedirect.com/science/a...

[Heykm01]

so you trade hot flashes for sore nipples and large breasts. Not sure that’s a great trade

[Gl448 in reply to Heykm01]

Definitely not a great trade in my opinion. Low dose EFFEXOR XR did wonders for my hot flashes, and I’m not getting gynecomastia from it.

[noahware]

A reduction of hot flashes should be a bonus benefit of add-back estrogen, not the main goal. The main goal should a reduction in loss of bone density! Secondary goals should be reductions in brain fog and fatigue and other bothersome effects of estrogen loss like, yes, hot flashes. But bone density is the big deal here.

I also wonder why they chose doses high enough to have the potential to lower T, when T is already being lowered by an agent like Lupron. As with dosing of transdermal E2, it would seem dosing of oral E4 when used along with Lupron should be just high enough to achieve the desired effects of increased bone mineral density and lowered hot flashes, etc. That way, the UNdesired effects of increased gynecomastia and nipple pain from high-dose E2 or E4 are reduced or avoided.

[kreg001]

PATCH test seems to have established transdermal estrogen as a viable alternative to ADH such as Lupron.

thelancet.com/journals/lanc...

[Chazem]

For patch users, any word or experience with using Tamoxifen to counter the gynecomastia? When to start it? If you already have nipple swelling or soreness would one stop the patch until that mostly (or completely resolves) resolves first? What dosage or range of dose would be? My doctor has no experience with the patch or Tamoxifen.