TPE, with blood withdrawn and reinserted without the plasma, has in a small clinical single-arm trial indicated remarkable benefits in markers of various kinds including DNA damage, cellular senescence and immunity (T-cells, B-cells, NK cells).
Downside appears limited. It remains to be seen if the benefits will hold over the long term. A larger trial is being set up, by the researchers at UC Berkeley and a clinic in the Bay Area.
Old plasma dilution reduces human biological age: a clinical study
24 August 2022