5 months ago, I posted:
"Non-PCa Prescription Drugs: Nitroglycerin"
I use a nitroglycerine patch to improve the oxygen supply to the tumor(s). Contrary to the predominant view on the internet, cancer doesn't "hate" oxygen. My patch generates nitric oxide [NO], which dilates blood vessels & thus improves the blood supply to the cancer & keeps it happy. Why would anyone want to do that? Because prostate cancer becomes really mean & nasty under hypoxic conditions.
I bring this up because I now recall a 2013 Giovannucci study that has a direct bearing on the NO issue  - & the full text is available, which wasn't free when I first read the paper.
"Nitrate and nitrite supplements have recently been shown to improve cardiovascular health, but there is concern that these supplements could contribute to the development of cancer."
"We conducted a nested case–control study within the Health Professionals Follow-up Study. Baseline blood samples were collected in 1994, and incident cases of prostate cancer were identified from 1997 to 2005. Baseline plasma levels of nitrate were measured in the 630 cases and 630 matched controls."
"We have found that baseline levels of plasma nitrate were not associated with risk of prostate cancer."
"... plasma nitrate seemed to be inversely associated with advanced-stage prostate cancer. The relative risk across extreme quartiles was 0.44 ... for the whole dataset ..."
"... and 0.30 ... for the fasting dataset.
So, as an indication of protection, fasting blood levels of nitrate are more significant.
Giovannucci seems surprised by the finding.
"Plasma nitrate comes from 2 sources. Nitrate can form endogenously from nitric oxide produced through the NOS pathway (as shown in Fig. 1) or from dietary intake, mainly vegetables. Approximately 80% of nitrate intake derives from vegetable consumption (6). A plate of green leafy vegetables such as spinach contains more nitrate than is formed endogenously from all NOS pathways in a day (30). Our study shows that vegetable intake seems to have a stronger association with plasma nitrate than total nitrate intake."
"Nitrate can be converted to nitrite and, subsequently, nitrite converted to nitric oxide "
"The conversion of nitrate to nitrite to nitric oxide occurs under hypoxic and/or acidic conditions when the NOS pathway is dysfunctional"
"... nitrate may affect prostate cancer tissues where a low pH/hypoxic condition exist, and the major NOS system does not function properly."