Jevtana stopped working. Considering Nubeqa

[Altamontt]

all in my profile. Diagnosed late December 2018. Multiple bone Mets. Started lupron and docetaxel. Brought psa down from 14.7 to .08. Also apparently dried up most Mets. Psa started to rise and started zytiga, which souped working in 3 months. Started Xtandi, which didn't work at all. Started Jevtana in March. Worked for 5 treatments. PSA down to .89. Next tx psa rose to 1.22. Next tx rose to 1.32. Oncologist ordered a bone scan and we discussed Nubeqa.

scan indicated multiple mets in spin and ribs and old mets active.

I'll see oncologist soon and sure he'll order PMSA scan.

Anyone used Nubeqa in circumstances such as this? Any other thoughts or recommendations?

Thank You. Hopefully TA will respond.

[EdBacon]

You can sometimes get more time out of another second-line anti androgen after doing chemo. There was clinical trial called CARD that showed this. There's more information here

nejm.org/doi/full/10.1056/N...

[GP24]

"scan indicated multiple mets in spin and ribs and old mets active. " In this case a PSA value of 1.32 is low.

If the PSMA scan shows PSMA expressing mets, you could get a Pluvicto therapy which radiates cells that express PSMA. An alternative would be Xofigo. I do not think Nubeqa will of much help in your situation, i.e. a chemo with Jevtana.

[Altamontt in reply to GP24]

Thank you.

[Rob1053]

I use it and find it causes no more side effects than just Lupron

[Tall_Allen]

Suggest you get both a PSMA and an FDG PET scan. Depending on their concordance, either Xofigo or Pluvicto may be indicated. Also, Provenge. Have you had a met biopsied for histology, IHC and genomics?

(BTW- your profile is blank)

[Altamontt in reply to Tall_Allen]

Oncologist called this morning. Scheduled PMSA September 1. Also bone biopsy.

[Tall_Allen in reply to Altamontt]

Ask for FDG too because you are heavily pretreated.

[TwilightZone]

Started 600 mg. Nubeqa twice per day on July 29, 2022. Keeping my fingers crossed because PSA just climed to 1.17 after after four years on Lupron and Eligard......................still taking both of them.

[Altamontt in reply to TwilightZone]

Good luck. Let me know how you do.

[Teacherdude72]

Diagnosed in 10/15, G9.Started Nubeqa 6/21. Psa undetectable.

Still Lupron too. Only new side effect loss of energy, big time loss. Offset by gym time five days a week and three days of scheduled exercise program.