Nubeqa after abiraterone resistant

[bandgeek]

Stage 4 Advanced with bone mets. PSA 222 at diagnosis.

After a year of ADT...Lupron, abiraterone and prednisone... I stalled at PSA 1.5. Then it increased over 3 months to 2.9. Medical oncologists took me off abiraterone and prednisone and replaced with Nubeqa. 30 days dropped to 1.6. No apparent side effects. Will test again in a few days. Currently on a 30 day testing cycle. I understand this medication is fairly new for treating advanced with mets. Not finding many with experience in this application.

Anybody have imput or info?

Bradley

[tango65]

Darolutamide is approved for non metastatic castration resistant prostate cancer and metastatic castration sensitive cancer.

If the cancer progressed during abiraterone , the cancer is castration resistant. If you had/have metastases, the cancer is mCRPC.

originalText

One can try darolutamide and see what happens but it may be better to try chemo when a new anti androgen drug fails instead of trying other of the new anti androgen drugs since there is cross resistance among these drugs,

urotoday.com/conference-hig...

You could discuss doing chemo or outside of the standard of care get Lu 177 PSMA treatment abroad if financially possible or in one of the clinical trials.

originalText

[KocoPr]

Here are a couple of links to read

healthunlocked.com/redirect...

Evaluation of Darolutamide (ODM201) Efficiency on Androgen Receptor Mutants Reported to Date in Prostate Cancer Patients

sciencedirect.com/science/a...

Breaking androgen receptor addiction of prostate cancer by targeting different functional domains in the treatment of advanced disease

[Shams_Vjean]

Has your Dr. mentioned triplet therapy? If not you might want to enquire about that.

[SF22]

67 yo currently on year 6 of my MPC journey. Surgery, Lupron, Casodex, zytiga, prednisone, radiation, chemo, xtandi. Tried Nubeqa for two months, PSA still on the rise. Only on Lupron now. Will start Keytruda next week.

[jackwfrench in reply to SF22]

Curious how long you were able to stay castrate sensitive? and PSA progression, both mapped to drug changes? Just got Lupron after RP two weeks ago, ready to come off Casodex and start abi.