Prostatectomy, radiation, chemo, Elig... - Advanced Prostate...

Advanced Prostate Cancer

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Prostatectomy, radiation, chemo, Eligard. What's next?

StevenMS profile image
13 Replies

Last month my PET scan revealed prostate cancer has spread t o my bones. I have read Estrogen has been used effectively to stop cancer progress and, in some cases, has actually decreased the size of the tumor.

Has anyone used Estrogen as treatment for advanced stage 4 prostate cancer?

At this point, it could make me look like Dolly Parton and I won't care.

13 Replies
NotAlwaysSunshine profile image
NotAlwaysSunshine

Hi Steven - I have not seen that article. I'll ask our MO on Tuesday.

Tall_Allen profile image
Tall_Allen

If your PSA continues to rise while taking Eligard, and it's keeping your testosterone at castrate level, I don't think estrogen will do you any good (other than for side effects). But you should be using Zytiga or Xtandi now. If you have pain from your bone metastases, you can also get Xofigo. Provenge is indicated too.

StevenMS profile image
StevenMS in reply to Tall_Allen

Eligard did keep my testosterone levels down. But it was a three year treatment and stopped 2 years ago.

So I'm thinking Eligard and estrogen, plus other treatments.

Tall_Allen profile image
Tall_Allen in reply to StevenMS

It didn't stop keeping your testosterone down 2 years ago, did it? It only stopped keeping your PSA down.

StevenMS profile image
StevenMS in reply to Tall_Allen

No. It kelp my testosterone down

Tall_Allen profile image
Tall_Allen in reply to StevenMS

Right. So if Eligard keeps your testosterone down, there is no need for estrogen

StevenMS profile image
StevenMS in reply to Tall_Allen

I heard it can stop, or even reverse, prostate cancer tumor in the bone.

Tall_Allen profile image
Tall_Allen in reply to StevenMS

It does that by stopping testosterone, just as Eligard does.

StevenMS profile image
StevenMS in reply to Tall_Allen

Oh. That's different than what I heard. Thank you!

tango65 profile image
tango65

If I understood correctly you have not been in androgen deprivation therapy for the last 2 years and the cancer showed mets in a recent scan. I assume your testosterones levels are above 50. The cancer is now, metastatic castration sensitive.

The SOC is androgen deprivation therapy plus chemo, or one of the second generation anti androgens.

Testosterone suppression is usually done with Lupron, Firmagon or similar meds but it can also be achieved using transcutaneous estrogen patches, according to the preliminary results of the PATCH study:

pubmed.ncbi.nlm.nih.gov/267...

This approach could have a better QOL:

pubmed.ncbi.nlm.nih.gov/277...

StevenMS profile image
StevenMS in reply to tango65

Thank you

dhccpa profile image
dhccpa in reply to tango65

But not used in USA, except by "rogue" docs? (Not meant in a bad way)

Shooter1 profile image
Shooter1

Kill the T. Add novel treatment... Xtandi worked for me for a few years then radiation to bones. Lasted about 7 mo. then again and it just stabilized, then xofigo which failed by allowing 4 new mets in first 3 mo. You have lots more options open to you at this point. Good luck and keep up the fight.... Life Is Good....keep living it...

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