Dendritic Cell Therapy

[TEBozo]

A friend of mine had extremely good results lowering his PSA to .003 using the Veritas Clini in Mexico. He had very advanced Mets in lungs and spine.

I'm here in Tijuana and getting treatment although my PSA June 22 was 0.55,only.

Dendritic Cancer Cell Therapy

Dendritic Cell Therapy is a powerful form of immune therapy used to fight cancer. It uses resources which already exist within the human body, namely, Dendritic Cells. They trigger the immune system to produce cells which fight cancer, and tell those cells how to do it.

What is the Dendritic cell’s function?

To understand Dendritic Cells, we must first understand how the immune system works. The body has both an innate and an adaptive immune system. The innate immune system is the first line of defence. It is none specific and fights any foreign antigen which enters the body. The adaptive immune system is the immune system which has learned how to fight specific antigens.

Dendritic cells act as the liaison between your different immune systems. They help the body to notice and recognise antigens which it needs to fight. In the case of cancer treatment, they teach your immune system to identify cancer cells, also called tumour antigens. This means that your adaptive immune system recognises cancer cells and can jump in faster to produce more of the cells which fight cancer. Unfortunately, Dendritic Cells are seldom active in adequate numbers.

What is Dendritic Cell Cancer Treatment?

Dendritic Cell Cancer therapy is a type of immunotherapy which helps to bolster your immune system and natural defences against cancer, by training and creating more dendritic cells.

It is highly advanced and targeted therapy, with a number of steps:

• Some dendritic cells are extracted from your body

• These cells are trained to fight the type of tumour which you have

• More of these trained cells are grown

• The cells are then re-injected into the body, acting as a dendritic cell-based cancer vaccine

• The dendritic cells move to the lymph nodes and activate, multiply and increase cancer fighting cells – T-cells and B-cells.

The benefits have been extensively researched and it has been proven a completely viable and safe alternative to conventional treatment. It has become a pillar in alternative cancer treatment, and has been adopted into many successful programmes across the world.

[MyDad76]

Thank you for sharing. Last year also in our country (Slovenia, Europe) study was published on dentritic cell theraphy. The paper is very scientific but in news it was reported that patients treated with it lived on average 16 months longer, results were better with patients without mets and side effects were very managable (flu like).

onlinelibrary.wiley.com/doi...

[Tall_Allen]

Dendritic Cell Therapy is FDA-approved and available in the US. It is called Provenge (sipuleucel-T).

[MyDad76 in reply to Tall_Allen]

Can one take Provenge while on Xtandi?

[Tall_Allen in reply to MyDad76]

Yes. I think it combines especially well with radiation (including radiopharmaceuticals) and chemo.

[Runner1957 in reply to Tall_Allen]

I have 1 pelvic lymph node treated with radiation and currently hormone therapy. If and when would this therapy be useful for my case? Thanks

[Tall_Allen in reply to Runner1957]

I don't think NHS approved it in the UK. In the US, you would have to have distant metastases and be castration resistant. Another dendritic cell therapy called APCEDEN is available in India.

[TEBozo in reply to Runner1957]

Would seem so.

[TEBozo in reply to Tall_Allen]

Understand that it's cost over $150,000 if a patient doesn't "qualify.?"

[Tall_Allen in reply to TEBozo]

One qualifies with mCRPC.

[TJGuy in reply to Tall_Allen]

Is Provenge available in other countries under the same name or is that the the name used in the US.

If so can I assume it cost much less as most procedures and drugs do in other countries?

Perhaps it's available at earlier cancer statuses oversea as well?

[Tall_Allen in reply to TJGuy]

I don't think Provenge available in countries outside the US. APCEDEN is available in India - it uses tumor tissue. TEBozo's friend received some sort of dendritic cell therapy in Mexico, where it was probably cheaper.

[tango65]

Just do Provenge, which is paid by Medicare and private insurances.

[TEBozo in reply to tango65]

Do you know anyone who got it approved "early" and who had success with it?

[Schwah in reply to TEBozo]

I reviewed some papers that took a look at the phase 3 study detail for Provenge. . Apparently when they broke the trial into groups by starting PSA, They found that the lower the starting PSA, the longer the median survival. This implied that like most PC DRUGS, the earlier you use it the better. Unfortunately it’s not approved for hormone sensitive. Therefore my dr prescribed it for me even tho I’m hormone sensitive and I paid out of pocket. Stupid pricing I paid but what the heck. I can’t take it with me.

Schwah

[TEBozo in reply to Schwah]

How much $?

[Schwah in reply to TEBozo]

It was ugly. About $160,000. I had them talked into half price but I screwed it up. Long story. If you’re serious about it PM me and I’ll fill you in.

Schwah

[Purple-Bike in reply to Schwah]

As you write, the earlier the better. Did you come across any discussion on whether Provenge could be even better when used for PCa at an undectable stage, possibly even a cure?

[TEBozo in reply to Purple-Bike]

My PSA went down from 0.55 to 0.51 in the past month. My hope I doing dendritic cell therapy is to strengthen my immune system to the point where it kills the remaining cancer cells in my body. I have a very mild fever after getting one IV and 4 injenctions yesterday

[Purple-Bike in reply to TEBozo]

How is it going for you at the Veritas clinic?

Am thinking similarly to you: killing micromets and circulating tumor cells. However, my PSA is even lower than yours its currently undetectable, so I will have nothing to measure progress against. As Schwah says, no data on efficacy for the hormon sensitive, so it demands a leap of faith and a big wallet to do it. Their answer may be biased, but if it's easy to do, could you ask Veritas their opinion on using dendritic cell therapy in a case like mine? (metastatic with brachy boost therapy and spot radiation, BRCA2+, hormone sensitive, in remission psa<0.1)

[TEBozo in reply to Purple-Bike]

If one has circulating cancer cells, and I believe we all do, the concept of super charging ones immune system makes good sense, at least to me. I am a 71 year old more active than most 50 year olds, working full time , determined to square off my life's decline curve. I'm much like the cartoon with 2 buzzards on a wire when one say to the other...."wait, Hell, I'm gonna kill something. "

[Schwah in reply to Purple-Bike]

Nope. No evidence it helps hormone sensitive or pre metastatic. Just inferences. And little downside other than the cost.

Steve s

[TEBozo in reply to Schwah]

I'm not sure there's enough data on relatively healthy men, do you think?

[TEBozo in reply to Purple-Bike]

Why not? It is supposed to seek out cancer cells.

[Purple-Bike in reply to Schwah]

Do you happen to have the data on breakdown of efficacy by PSA grouping easily available? If not I'll search.

[tango65]

They approved for me when my PSA started to go up after ADT treatment.

[TEBozo in reply to tango65]

And did you use Provenge?

[tango65 in reply to TEBozo]

No because I have an autoimmune peripheral neuropathy and the immunology doctors were concerned that the vaccine could make it worst.

[Prostatefighter]

There is also a place called immunicura in Spain which does dentric cell therapy and can be administered in the UK.

[Purple-Bike in reply to Prostatefighter]

Do you have any idea how that therapy compares to Provenge?

[TEBozo in reply to Purple-Bike]

If not identical, very much the same.

[Purple-Bike]

Thanks. That company found me and proposed their therapy for me. I asked them if it was Provenge and the marketer said no. I suspected it was similar and your opinion reinforces this.

[Spyder54]

TEBozo, just saw on News there is some big disturbance at US Consulate in Tijuana w cars on fire blocking streets. Not to scare you, just to make you aware and keep your head on a swivel. Will hear about Dendritic Cell progress as you go. Best of luck, Mike

[TEBozo in reply to Spyder54]

Thanks. Been in touch with the clinic and they say that it's between the cartel and cops. We stay at the Quarz hotel where most of the medical tourists stay. Very nice upscale place and safe we'll be driven to and from hotel clinic and airport. Dozens of bariatric patients in fact there is a Mercedes Van picking a new group each morning.

[Spyder54]

econfinnews.co/Mexico-viole...

[Charles4212]

I had provenge in July 2021. It kept my psa down for eight months. Medicare paid the bill $61,000 .00

[TEBozo in reply to Charles4212]

Charles, where did you have it administered and what insurance do you have please?

[TEBozo]

SO far my monthly PSA has been around 0.50.