Zytiga strength

[Chrisbaird]

After 18 months on zytiga firstly 1000gm then reduced to 500gm after 3 months with 5gm prednisone PSA been sitting at < 0.01 for a year I’m this last few weeks finding discomforts in stomach seems water retention / stomach bloating thinking dosage is effecting my liver enzymes Monthly blood test this week maybe a lower Zytiga dosage could be answer or switch tables anyone else had these symptoms or thoughts thanx

[tango65]

Water retention will show as edema in the legs and a rapid increase in your weight. Metabolic panel will tell you if the liver is affected.

[Chrisbaird in reply to tango65]

Thanx I have monthly blood test Tuesday so by Friday will know results. Weight has not increased or water in legs I think it’s liver or kidney toxicity in some form again

[Hidden]

Your MO might switch you from prednisone. Prednisolone is more expensive but it doesn't tax the liver as much as prednisone. It also might help reduce kidney stress.

Prednisone vs Prednisolone - What's the difference?

drugs.com/medical-answers/d...

[Chrisbaird in reply to Hidden]

Thanx RSHI I have a video call with Urologist in 2 weeks so I’ll suggest that to him.

[6357axbz]

Dexamethasone seems to be the preferred option to prednisone

[katartizo61]

get your gallbladder checked as well. Zytiga is fat soluble and can result in high gallbladder numbers. there are several good adjunctive care modalities that can help

[Chrisbaird in reply to katartizo61]

Thanx katartizo I’ll mention that when have video review with MO

[leo2634]

I'm on Zytiga for about four years now along with Prendisone also PSA 0.1. I don't have enough fingers to count the life changing things that happen to our bodies. I'm also so very grateful to still be alive. I asked my Doctor in 2018 to promise me he would keep me alive to watch my Grandkids grow up so far so good. Never give up Never surrender. Leo

[Chrisbaird]

Thanx Leo Glad zytiga has been working well for you hopefully I can resolve my slight problem and continue like you

[reb77]

I started out with 4 Zytiga tablets and now taking just one with food. I started itching and after about a month of this my Oc reduced the dosage. No itching now.

[Chrisbaird in reply to reb77]

Reb77 I guess you were 4x 250gm I was told tablet 1 hour before food in morning Never had itching more energy problem since starting on zytiga

[Poowater]

Go for advice to your oncologist.

[Electrician]

Have been on Zytiga 1000mg & prednisolone 10mg for 4 yrs 3 months. PSA at 0.01 for that time. Am now experiencing extreme fatigue and stomach discomfort and am considering halving the dosage as am NHS co-pay which is proving too expensive at £1800. per month. Am wondering do I take food with lower dosage? Also can’t understand why MO has kept me on full dosage for so long as most people on this blog seem to reduce after 2 years! Any thoughts would be appreciated.

[Chrisbaird in reply to Electrician]

I had to reduce to 500gm after 2 months as you see from my comments as liver toxicity known from monthly blood tests. For 15 months I have taken zytiga at least one hour before food. 7am 5gm prednisone with food PSA been < 0.01 for a year but like you stomach discomforts and fatigue increased more recently whether I need to reduce the dosage to 250gms daily as sometime it’s know your take a medicine at too higher dosage and not needed can irritate your stomach so when I next have telephone appointments with my urologist I will discuss this situation. Electrician I hope you get sorted and my thoughts help you

[Chrisbaird in reply to Electrician]

I don’t pay for my medication I omitted to say to you. Your cost seems very expensive … !!!

[Electrician]

Did you have other treatments before you took Zytiga? As I refused chemo that was my only option but was told it was not available on the NHS . As this was under review my MO said I would probably only have to pay for it for 1 year! Once you start on co-pay they won’t give it you free but if you were diagnosed during Covid anyone could get it! Sod’s law! I am going to try half dosage and see how I get on and intend to tell my Oncologist next time he phones .

[NickJoy in reply to Electrician]

That is terrible - the MO should do something about it! Is it cheaper to get a generic version? Not sure if it's available in UK but you could ask the MO maybe?

[Chrisbaird in reply to Electrician]

I never had any chemo. Just put on zytiga /prednisone Dec 20 together with 3 months of. H T then 3x monthly since then