Does the effect of Docetexal goes away after 2 years in this case?

[Nick2019]

Summary:

Age:55

16/06/19 PSA: 400

(some ayurvedic treatment)

26/07/19 PSA: 697

26/07/19 I-PET scan : heterogenous markers suv (max 52) including mets

Doctor suggested luporide every after 3 months including chemotherapy (docetexal) every after 21 days

20/10/19 PSA: 0.72

30/10/19 II-PET scan: tumor size reduced to suv max 20, in two more areas, no new lesion seen

Total chemos: 6 cycles

Doctors suggested to stop chemo but continue luprolide

Follow up every after 3 months and next PET scan after 6 months

After 3 months

Psa is 0.157

No chemo only luprolide injection every after 3 months

PSA updated as on 20May 2020 is 0.757

By God's grace everything is fine so far. At times there are hot flashes. Secondly there is lot of fatigue and pain also. But due to lockdown, unable to visit hospital for 3rd PET scan. Hope it goes fine ahead!

[Hidden]

It's the not effects of chemotherapy going away that you are seeing, it's more likely the cancer adapting to a low testosterone environment. It's called Castrate Resistance.

It's what happens to all us eventually. When your PSA gets above 2, you will probably start having a discussion with your doctor about adding either Enzalutamide or Abiraterone to your ADT luprolide.

[Tall_Allen]

That's a great response to chemo. If your PSA continues to rise and new metastases appear, you may want to get abiraterone next.

[JamesAtlanta]

What an amazing response! Congratulations!

Something is causing your PSA to rise now. I would talk to your doctor about adding Zytiga to Lupron. When my PSA started to rise from undetectable (after Lupron, radiation and chemo) to 1.8, I added it. Was fortunate that I had a great response and it went back to undetectable the first month. I had no additional side effects.

Best of luck on your journey. Please keep us posted!

James

[Nick2019 in reply to JamesAtlanta]

Thanks

[Bodysculpture in reply to Nick2019]

Spoke to my GP

HE said it takes 6 to 8 weeks for the effect of the 6 doses to lessen

I think you are asking me how long will it lasts before is shows up somewhere else ?

It varies from person to person but my GP said he doesn't expect to see me in a long time

Many in this group have been living for several years with APC

They inspire me daily

Thee is hope for us yet

[Nick2019 in reply to Bodysculpture]

Thanks a lot dear!

[Bodysculpture]

Nick I am on the same treatment plan you are

And I am hoping for results like yours well done

My last chemo tomorrow 6 all together 21 days apart plus 3 monthly hormone injections

As a personal trainer I can confirm exercise is one of the best things to can do

Especially resistance exercise

Get a few dumbbells and play around a bit lol

[Nick2019 in reply to Bodysculpture]

Thanks

[Nicnatno]

Nick, I was on the same treatment plan. My last chemo treatment was July 2017. In April 2020, my PSA was up to 6.5. My Onc put me on Xtandi.

I don't see him again til July 22nd and will find out what my PSA is. I was dx in March 2017, PSA 415 and Gleason 8. Take care and be well.

Nick

[Bodysculpture]

Looking good Nick

Congrats let's keep this going

Finished my 6th and hopefully last chemo today decataxil

Hoping to get ths tests you have

My PSA was 13.5 when detected

Today it was 1.63

Mets in ribs

Small amount in the spine and shoulder

Having another scan before I see my ONCOLOGIST ON THE 26

MY FJNGERS ARE CROSSED