Phase 1 CBP/p300 Inhibitor FT-7051 Trial

[billd50]

Is anyone familiar with the following trial:

Phase 1 Study of the CBP/p300 Inhibitor FT-7051 in Men with Metastatic Castration-Resistant Prostate Cancer

I have a PC colleague who recently had a PET scan that found cancer cells in the L5 to L3 vertebrae. Apparently, his insurance won’t cover the next chemo drug providing incentive to join the trial.

[Tall_Allen]

The bromodomain inhibitors are a hot topic right now. They are trying to cripple the PCa cells so they can't replicate. Here's the initial report of the dose-finding trial:

aacrjournals.org/mct/articl...

[Schwah in reply to Tall_Allen]

What is your opinion on the potential efficacy of this line of treatment TA? And what are “TEAEs”?

Schwah

[Tall_Allen in reply to Schwah]

Platelet loss, fatigue and nausea are the serious TEAEs. About a dozen different clinical trials are in the works, so many think it will be effective. If effective, it is only effective in combination, as with enzalutamide or PARP inhibitors.