I’m new here. Does Carboplatin sound right for my next course of treatment?

[mas65]

Hi All,

This is my first post on this forum. I have learned so much in a brief time!

I currently have widespread bone metastases based on a recent PSMA PET scan. Currently on Lupron but stopped Zytiga because my PSA is rising. My PSA increased from 0.13 to 0.52 in a 3 three month span. My Oncologist wants to begin chemo with Carboplatin, but what other effective options are there. I've brought up the recently FDA approved drug Pluvicto, but he shows little or no interest.

[NotAlwaysSunshine]

Tell us more about yourself. How old are you, where are you, when were you diagnosed. Do you have an genetic mutations etc... Have you tried any clinical trials? Put this in your bio.

[mas65 in reply to NotAlwaysSunshine]

I updated my profile. Thank you!

[NotAlwaysSunshine in reply to mas65]

Have you have any family members with PC ? Any cancer in your family?? Did you do any genetic testing? Do you live close to an excellent cancer center/teaching hospital??

[mas65 in reply to NotAlwaysSunshine]

I had a great uncle who had PC. I have not had any genetic testing done as of yet, but will be getting it done soon.

I am being treated at Froedtert&MCW

which is a teaching hospital for the Medical College of Wisconsin.

[Tall_Allen]

To get Pluvicto in the US (other than in a clinical trial), you have to do chemo first.

[mas65 in reply to Tall_Allen]

Thank you for your response. Sounds like chemo is the next step. Radium 223 therapy was also mentioned, but now the Dr. is going with Carboplatin.

[Tall_Allen in reply to mas65]

You can combine docetaxel and Xofigo ( reducing docetaxel dose.) I don''t know if it's still a good idea when you add carboplatin to the mix. Maybe email him this link and discuss:

ejcancer.com/article/S0959-...

Maybe one of these clinical trials is near you:

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

[mas65 in reply to Tall_Allen]

Thank you! I will definitely discuss.Lot of times I feel rushed during my visits, as my situation has reached a point of switching treatments, I will need to be more adamant in having a thorough discussion.

[Tall_Allen in reply to mas65]

I've found it helps to email the links ahead of time with a short note: "I'd like to discuss this with you at our next appointment." That way he has time to review and think about it without feeling rushed.

[mas65 in reply to Tall_Allen]

👍

[subliminaldood in reply to mas65]

With a PSA number under 1.0 you should not be rushing into anything. you have plenty of time. As you can see here many of us would love a number that low. Docetaxal is the usual first chemo.

[mas65 in reply to subliminaldood]

Thank you. I was a little shocked when I saw the results of the PSMA scan. A lot of black circles throughout my skeleton. No sign of metastasis to the soft tissue or organs though.

[RusLand]

Hello and welcome to the society of cancer kissed!)) I also started my journey in 2016 with multiple bone metastases with PSA at 1850 ng/ml.. And nothing, still in the ranks! With multiple bone metastases, it is definitely necessary to start with chemotherapy in combination with those hormonal drugs that you are already taking or in combination with those that Tall_Allen offers.. It is unclear whether you have been prescribed anti-bone resorption drugs (Xgeva, Zoledronic acid)? To choose a drug for chemotherapy, I would personally wait for the results of a mutation in the BRCA1/2 genes! There are studies in which it is said that with mutations in these genes, the best choice is the platinum group (Carboplatin) of chemotherapy drugs, and not taxanes (Docetaxel).. We need to search the Internet, and maybe Tall_Allen will tell us something. There are also studies that say that if there are BRCA1/2 mutations, then with a combination of Olaparib and radioligand therapy using the PSMA ligand, the effectiveness of such treatment is higher.. Discuss all this with your doctor as well. Good luck to you and God bless us all!

P.S. By the way, your profile is still empty!

[andrew61]

I just had pretty good success with Jevtana plus Carboplatin on my bone Mets. PSMA scan after the first 2 infusions showed continued spread but a scan after 5 infusions a rescan showed most Mets were resolved or healing. Now on to a clinical trial for me.

[j-o-h-n]

Greetings mas65,

Would you please be kind enough to tell us your bio. Age? Location? When diagnosed? Treatment(s)? Treatment center(s)? Scores Psa/Gleason? Medications? Doctor's name(s)?

ALL INFO IS VOLUNTARY, but it helps us help you and helps us too. When you respond, you might want to copy and paste it in your home page for your use and for other members’ reference.

THANK YOU AND KEEP POSTING!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 04/10/2022 6:54 PM DST