I concluded my chemo in October' 21 . My psa since then has been 0.2. Just found out that my T is 0.27. What does this mean for me? On ADT.

[Ashikpong]

I concluded my chemo in October' 21 . My psa since then has been 0.2. Just found out that my T is 0.27. What does this mean for me? On ADT.

[tango65]

This isolated value does not mean anything. If the PSA continues to increase and your testosterone is less than 50, is indication the cancer is becoming castration resistant. some will say to wait until PSA is 2 or higher, to declare the cancer castration resistant.

If PSA increases I would request a PSMA PET/CT when the PSA is around 0.5.. If there is not radiographing progression of the cancer, you could discuss continuing on ADT and doing nothing else and repeat the study when PSA is around 2.

New treatment will be indicated if there is evidence of radiographic progression. There are multiple treatment options to keep controlling the cancer.

[Ashikpong in reply to tango65]

Thanks. My psa has been 0.2 since after 4th chemo cycle . I still have my prostate gland and feel good. But with my T so low I wanted to know what implication that might have

[CAMPSOUPS in reply to Ashikpong]

You of course need your T to be low to limit the progression of the cancer.Side effects of no T are many and affect men differently from man to man.

The more commonly side effects:

No libido

shrinkage of genitals

hot flashes

loss of muscle mass

weight gain

loss of strength

loss of stamina

loss of body hair

loss of body odor

cognitive decline

mood changes including possible depression

[Ashikpong in reply to CAMPSOUPS]

Thanks Campsoups

[CAMPSOUPS in reply to Ashikpong]

Well sure. I'm sorry I couldn't sugar coat the answer. It's not a very happy thing to look at. But if you have stage 4 the chemo and Testosterone blocking drugs extend long term and progression free survival.I am glad I was offered chemo and I am currently taking Zytiga.

I started chemo and Lupron/Eligard at about the same time so it was hard for me to know what side effects were coming from chemo and what side effects were coming from Lupron.

[GoBucks in reply to CAMPSOUPS]

But other than those side effects, how was the play?

[CAMPSOUPS in reply to GoBucks]

Doing good thanks. Started November 2019. I have responded so far to treatments. Effect of chemo and Lupron wasn't enough by around April or so of last year and added Zytiga. I'm a lucky guy. Life is good while you're alive.Maybe you saw my bio. Started at PSA 1621, bone mets skull to shins, and lymph nodes pelvis to collar bone.

Until a little over a year ago I was for about 23 years only an hour and 15 min. from Milwaukee. Northern suburb of Chicago.

[CAMPSOUPS in reply to GoBucks]

Not a big deal but did I answer your question.I didnt know if "how was the play" was a typo or a reference to how did things go along the lines of how did thing play out.

[GoBucks in reply to CAMPSOUPS]

Actually an old Abe Lincoln joke: other than that Mrs. Lincoln, how was the play? Glad you are ok. Indeed, life is good!

[CAMPSOUPS in reply to GoBucks]

Oh yea. How soon I forget. Comes with the territory adt lol.

[cancerfox in reply to CAMPSOUPS]

But on the positive side, my skin complexion has been blemish-free since the ADT!

😎

[CAMPSOUPS in reply to cancerfox]

Same here. And amazingly no foot odor. I was notorious for putrid foot odor.

[tango65 in reply to Ashikpong]

Best of luck!!

[Tall_Allen]

It means your ADT is working just fine.

[j-o-h-n]

Those results should put a ping in your pong...........

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 02/21/2022 7:04 PM EST

[AlanMeyer]

Just a note here to remind people that testosterone is measured in different units in different countries. In the U.S. I think ng/dl (nanograms per deciliter) is common. In the U.K. I think it's nmol/L (nanomoles per liter). When posting in this HealthUnlocked group of international participants, it might be a good idea to post units as well as numbers. There's a conversion calculator here: balancemyhormones.co.uk/tes...

[Doseydoe]

In Australia, the normal range for testosterone is quoted as (8.0 - 38.0) nmol/L. I went on ADT at the beginning of 2020 and underwent 9 Docetaxal infusions and 20 Radiation sessions. This reduced my PSA to 0.02 and my testosterone to 0.7 respectfully. Happy with that and I consider myself a lucky man. My ADT rythm is now one three month shot of Eligard per year. I monitor my PSA levels every two months or so and when the trend of the results show a doubling three times in a row, I organise to have another shot of Eligard. This is currently working for me but everyone different. My Oncologist would prefer me to have a shot every three months but as my T and PSA remains low, he is willing to watch and see how my levels go. It's been six months since my last ADT shot and while I still have all the same side effects as others have described, they are less intense. I will probably keep this regime up for the time being and add a cystoscopy to check for any progression of the growth which invaded my bladder. Early on I discovered that while my PSA was low, the PCa in my bladder was continuing to thrive and therefore I needed a TURBT and Radiation to get it under control. I hope this precis of my story helps your understanding of APCa and your own situation. All the best, 😎 DD.

[Ashikpong in reply to Doseydoe]

Sure. Thanks for taking the time

[MateoBeach]

So you were de novo (at diagnosis) metastatic to bone in may 2021. Placed on Lupron ADT and have now gone through docetaxel chemo. That is appropriate. The PSA level is nothing to worry about at this time, especially since you still have your prostate. The question, it seems to me, is whether you should add an advanced AR agent NOW to make it a triple-therapy. That would be abiraterone +p or darolutamide as these have been shown to provide a large survival benefit over docetaxel + ADT in de novo metastatic patients. Even though you are not starting it at the same time as the docetaxel, it still could (might) be very beneficial, in spite of the delay? Worth discussing with your MO now. See other threads on triplet therapy such as PEACE-1 on this site and elsewhere.

[Ashikpong in reply to MateoBeach]

Thanks for your advice . I'll surely discuss your suggestion with my MO on my next appointment.

[MateoBeach]

ARASENS Trial was the one with darolutamide. PEACE-1 with abiraterone.