Estradiol just won't go down

[Arthur479]

None of my docs understand how my estradiol remains highly elevated (above 100), My T is next to zero, I am lean, DHT in the normal range, taking 3 mg of Arimidex for several months.

The estradiol was never checked until after my PSA began to rise after several month of successful BAT therapy. So I have no idea what it was prior. Maybe that is the way it always was.

However, my understanding is that this reading is not at all desirable for PCa.

Best anyone can come up with is to try tamoxifen which blocks the estradiol receptors. I have been taking DIM, Chrysin and Grape Seed extract, but none of those seem to put a dent in this issue. Any other experiences with this and how to deal with it?

[Arthur479]

3 daily

[Arthur479]

Nalakrats thanks, meeting with my MO today. Will bring it up. Do you have a link? Will look up myself that potential issue myself.

[E2-Guy]

I apply about 3mg of E2 gel daily to keep my PCa under control. My E2 has been in the range of a premenopausal woman for over three years now. PSAs have been undetectable.

[EdBar]

I’ve been using estradiol patches per Snuffy Myers for about 7 years now for relief from hot flashes and to maintain bone health. Dr. Sartor has no problem with their continued use now that I see him since Snuffy retired.

Ed

[Horse12888]

What's the imperative to lower E? People use high-dose transdermal estradiol as ADT with great success. Isn't this true?

[Break60]

Mine is a lot higher but I’m using estradiol patches as AdT

[PhilipSZacarias]

Hello Arthur479, Your case is indeed puzzling. The only suggestion that I can make is that BAT has elevated the sex hormone binding globulin (SHBG) and that it has bound some of the excess testosterone (T) and is slowly releasing it. The T is immediately converted to estradiol (E2). The fact that DHT is in the "normal" range seems to support this possibility. As Nalakrats has mentioned, perhaps Arimidex (to block conversion of T to E2) is one way to decrease E2 levels. Adding a 5 alpha reductase inhibitor such as Avodart may be indicated as well to decrease DHT levels. I am not a doctor, so these suggestions should be discussed with your MO's. Cheers, Phil

[Arthur479]

You guys rock! I am very grateful for the insight. Lots to discuss wit the MO today. Will report back.

[pjoshea13]

Hi Arthur,

I will just mention one situation that would cause high levels of E2, & that is a genetic polymorphism of CYP19A1, which encodes for aromatase.

If you had that, you would likely have experienced gynecomastia as a boy.

Best, -Patrick

[Shorter]

This may seem weird, but I'm going to throw it out there since you weren't previously tested for estrogen . I know more than 1 person who is Intersex. One of them didn't even know it until last year at 67 years old. The surgeons found an ovary while removing something I think was called Large Cell Tumor if memory serves me right.

[Arthur479]

MO is not sure why E2 is so high. Going to try thyroid panel.

Showed him Patch Arm of Stampede trial. Said it seemed like an offshoot of an old estrogen therapy that was halted due to thrombotic events. Compared Patch trial to Lupron in terms of T suppression. No decision made at this time.

Was much more interested in the results of my upcoming. PSMSA scan. Looking forward to stereotactic treatment if results indicate they might be useful.