What dosage of estradiol patches to mitigate adt side effects

[Tnjw]

Reresearch indicates that the use of estridol patches while on adt may mitigate some of the side effects of adt. My question is on the dosage of estradiol patches. Does anyone have information or experience with the proper dosage of estradiol patches to reduce adt side effects ?

[pjoshea13]

The important thing IMO is that estradiol [E2] should not be below 12 pg/mL, since bone loss can be rapid.

One should perhaps aim for 20 pg/mL.

The lowest dose E2 patch will do the job & it may not be necessary to use it daily.

I believe that the lowest Vivelle-Dot patch is 0.025 mg.

It will not increase the risk of a blood clot.

-Patrick

[pjoshea13 in reply to pjoshea13]

Dr. Myers touches on this at about the 3:30 mark:

askdrmyers.wordpress.com/20...

-Patrick

[Tnjw in reply to pjoshea13]

Thank you , will share with doctor

[Tall_Allen]

0.10 mg/ twice a week:

goldjournal.net/article/S00...

[Tnjw in reply to Tall_Allen]

Thank you TA, will share with doctor who is open to trying the patch

[MateoBeach]

I tried ADT solely from E2 patches per the revised PATCH trial protocol. This used 4 patches and changing one out every day. They are semi weekly (4 day) patches and the strength is 0.10 mg/24 hours.

That brought my T down over the course of a month but not to below 20 my/dL. So I punted and took a shot of degarelix to promptly get me there. To my delight and surprise I had none of the severe SEs I had on previous ADT. So I am a believer in Estradiol with ADT

Now to answer your question, I reduced my dosage and found I could use just one or two patches at the 0.10 strength and change them out every two days. Not 4 days as most of the estradiol is released and absorbed in the first 2 days. Your mileage may vary.

Personally I do not worry about my E2 level being pretty high if my PSA is low and not rising. If breast swelling and tenderness begins developing go on tamoxifen 10 mg daily to prevent gynecomastia.

[Tnjw in reply to MateoBeach]

Thank you for sharing great information. This site is truly a wonderful resource. My Dr. is open to prescribing the patch and researching the dosage. I will share this info with him.

[EdBar]

Ive been using patches for almost 6 years now and they work great, I used to have really bad hot flashes, now I get them now and then but no where near what they were. I use 0.1 mg twice a week, originally prescribed by Dr. Myers but my other docs haven’t had any problem prescribing them now that he’s retired.

Ed

[Tnjw in reply to EdBar]

Thank you for yout reply. Will share with my Dr. who is willing to prescribe the patch

[EdBar in reply to Tnjw]

Shouldn’t be an issue getting a script, if you search on line there’s plenty of data supporting patches to help with side effects. And they don’t cause coronary issues because they are absorbed through the skin unlike pills that are absorbed through the liver, so don’t let them give you that line, they should know better.

Ed

[Tnjw in reply to EdBar]

Dr. is willing to prescribe the patch but somewhat uncertain as to dosage. Said he will research . On your usage of the 0.1mg twice weekly what is frequency of patch change out? As example, one on for 24hrs Tue and the second on 24hrs later in the week.

[EdBar in reply to Tnjw]

It will give you options on the box that the patches come in. You’ll change a patch after three days and then the second one after four days and you just follow the same schedule every week.

Ed

[Tnjw in reply to EdBar]

That makes sense, thank you

[Sunnyby11]

Are you on Lupron alone or with Zytiga ??

[Tnjw in reply to Sunnyby11]

Firmagon only

[Sunnyby11 in reply to Tnjw]

Thanks

[Ramp7]

This seems readily available. Is a prescription needed?

[Tnjw in reply to Ramp7]

Yes