A study a few months ago said that certain strains of probiotic can help ADT work for a longer period of time - inverse.com/mind-body/gut-h....
"Abstract: The microbiota comprises the microorganisms that live in close contact with the host, with mutual benefit for both counterparts. The contribution of the gut microbiota to the emergence of castration-resistant prostate cancer (CRPC) has not yet been addressed. We found that androgen deprivation in mice and humans promotes the expansion of defined commensal microbiota that contributes to the onset of castration resistance in mice. Specifically, the intestinal microbial community in mice and patients with CRPC was enriched for species capable of converting androgen precursors into active androgens. Ablation of the gut microbiota by antibiotic therapy delayed the emergence of castration resistance even in immunodeficient mice. Fecal microbiota transplantation (FMT) from CRPC mice and patients rendered mice harboring prostate cancer resistant to castration. In contrast, tumor growth was controlled by FMT from hormone-sensitive prostate cancer patients and Prevotella stercorea administration. These results reveal that the commensal gut microbiota contributes to endocrine resistance in CRPC by providing an alternative source of androgens."
I presumed that taking a couple different probiotic supplements might help achieve that effect but someone on this site "TA" said the probiotic supplements can produce increased amounts of Folate and B12. I did a bunch of research and found that most of the probiotics on the market do promote B12 and folate, which have been thought to be growth-promoters of Advanced PCx.
I did find one probiotic that seems like it might be helpful to us. It does appear to increase folate and B12, but the probiotic could be used intermittantly as necessary to heal the gut. You can tell me your thoughts on it. I'm not an expert on the topic but I read several studies on probiotics to find something that might be helpful, instead of promoting cancer. This is the item: biogaia.com/product-country... Here is more info on L.Reuteri - ncbi.nlm.nih.gov/pmc/articl....
This new study (link below) related to melanoma basically says that immunology treatment patients did better if they ate a lot of fiber than if they took probiotic supplements. This is a summary of the study:
medicalnewstoday.com/articl...
Basically, it says that prebiotics such as fiber can be helpful, and some probiotic supplements can be harmful. The same probably applies to prostate cancer. They talk about how antibiotics can help by killing all the bacteria that promote the prostate cancer, but since it kills the good bacteria too, then it's hard to know whether it is beneficial. Maybe if you eat lots of fiber while you take the tetracycline or doxycycline, then you can maximize the benefits...who knows.
I've been focusing on trying to determine what foods help to promote the type of probiotic strains that studies say are linked to greater longevity (akkermansia (blog.undoctored.com/akkerma..., Prevotella stercorea (bananas, mangos) and one or two other strains that I can't recall), then continue to or add those foods to my diet. I'm giving away all my probiotics, except for the one I mentioned above. I'm thinking about continuing a prebiotic supplement, continuing the high fiber healthy diet, and maybe adding chicory root supplement.
Please realize that I'm not a researcher at a cancer institute, so if you don't like the way I have phrased things, then please focus on the intent. I'm just trying to stimulate conversation and bring intelligent, actionable ideas to the forefront. I also don't want people taking a load of probiotics, if they might be shortening the effectiveness of ADT treatments. The two article links above are based on real studies that were done. If you want to look up the studies, go ahead. One of them is observational, with a small number of participants. Take it with a grain of salt or don't take it at all. It's all I could find, but I think it is helpful.
On a separate point - The cause of my activity the last couple days, is from drinking a can of Rise Nitro Brew each day, and my energy has increased by leaps and bounds. You might want to check it out. I stumbled on it by accident in the grocery store.
Lastly, in the prostate cancer/bacteria link above, it says, "abiraterone blocks the production of androgens from bacteria" ... Does anyone know if Darolutimide (Nubeqa) blocks the production of androgens from bacteria?
PTEN loss is not a determinant of time to castration-resistance following androgen-deprivation therapy in prostate cancer
chronic inflammation.
