Where do I go from here?

[davidw777]

I need to decide on a course of action.

Dx June 2021 and recently reached undetectable – details in profile.

Here are my options (maybe others?):

1.Keytruda now (genetic test shows MSI-High)

2.Docetaxel now

3.Maintain status quo (Zytiga + Firmagon) until change in PSA

4.Radiate mets

5.Treat primary

MO suggested starting Docetaxel now and save Keytruda until PSA starts rising. He said since I have the SPOP mutation, I should have a longer than average favorable response to hormonal therapy.

I welcome your input.

[Tall_Allen]

So why not combine Keytruda and Zytiga? There have been almost miraculous remissions with Keytruda among men who are MSI-hi. I don't understand waiting.

[davidw777 in reply to Tall_Allen]

With my PSA now at undetectable, would Keytruda be as effective against the senescent cells?

Or is it similar to chemo where it’s better to wait until they are actively replicating again?

[Tall_Allen in reply to davidw777]

Keytruda is approved for any cancer where the patient is MSI-hi. It is unique. You should jump on it ASAP.

[j-o-h-n]

I take keytruda for a lung melanoma and it works....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 01/11/2022 7:45 PM EST

[Vindog29]

I'm sorry I just read this..my husband tried Docetaxel,Zytiga all failed. Repeat biopsy showed MSH2 high got 2 treatments of Keytruda PSA undetectable 3yrs tomorrow all metastatic tumors shrunk from JUST 2 treatments