Would any of you know why my Dad's PSA is rising during treatment. He is currently on a Peace 111 trial (Xofigo & Xtandi with monthly zometa) extensive bone mets, some lymph nodes, no organ involvment. He has 1 more xofigo out if 6 left, but his PSA has gone up to 99.1 from 30 (June), he has CT scan and bone scans every 6 weeks which show disease is stable with some areas of healing, no progression. But I'm so confused why the PSA is still climbing, shouldn't the xtandi be bringing it down? He also has 3 monthly decapeptyl injections. Today he is having 1 unit of blood transfusion as his hemoglobin is down to 8.3, iron and platelets down too.
Many thanks in advance for your comments.
rising PSA on cabazitaxel !
PSA rising but scans clear
PSA rise during/after consolidation radiation 
Early treatment prior to PSA rising when my cancer doesn't seem to produce much PSA
PSA DECLINING WHILE IT WAS RISING
The best answer to your question is that you are not reporting anything we have not heard/read. When the scans are showing resolution of Bone Mets, and reduction in their size----what happened to the cancer cells? Well to answer-->when they died they threw off bits and pieces of their structure/body--in so doing they released their Protein Antigen---or more commonly called their PSA. The body will take time to rid these pieces of space junk. And usually, if the treatment is successful, there will eventually be a drop in PSA. The most important thing is what the scans are showing. And so far your scans are in your favor.
Nalakrats