What is normal testosterone fluctuation under Eligard and abiraterone?

[6357axbz]

Anyone know if a change in t level from <3 to 50 over 2 months is normal under double ADT?

Thanks

[GP24]

When you add Abiraterone testosterone should be <3 ng/dl. Therefore 50 is too high. See your doctor and get another testosterone test. The lab may have made a mistake.

[6357axbz in reply to GP24]

Thanks, I agree. I’ve sent a message to my MO. It’s possible they screwed up and gave me a 3 month rather than a 6 month Eligard injection the last visit. Appreciate your speedy reply.

[GP24 in reply to 6357axbz]

I always assumed Abiraterone would work just as well without Eligard. Just the trial was designed to add Abiraterone to Lupron and therefore Abiraterone was approved in combination with ADT. Please tell us when you found the reason for the rise in T.

[6357axbz in reply to GP24]

Will do. Thanks

[Tall_Allen]

50 is way too high. Maybe try Orgovyx instead of Eligard.

[6357axbz in reply to Tall_Allen]

I agree. My MO, Paul Corn just replied to my concern via his nurse, “Dr. Corn indicated he's not concerned about testosterone as the PSA is still low. Testosterone levels can fluctuate a bit.”

[Tall_Allen in reply to 6357axbz]

Maybe retest in a week in the morning.

[6357axbz in reply to Tall_Allen]

I sent a request for another order for T

[6357axbz in reply to Tall_Allen]

My 2nd request today to Paul Corn fell on deaf ears. His answer is a repeat of the one from earlier today, “Mr. Nelson, Dr. Corn said that testosterone levels can fluctuate a bit. Nothing to be concerned about. Your PSA levels have been low.

I also checked your medical administration records and you were given the 6 month eligard injection.”

So I’ve requested a re-test order from my PCP who is very cooperative with me.

[6357axbz in reply to Tall_Allen]

Well Mr Corn seems to have done a 180. Here is his unexpected latest message to me:

You can sure check your Testosterone level again and we will send you another lab order.

It is odd for your T level to go up - particularly on abiraterone. You got the 6 month leuprolide shot but even if you did not, abiraterone usually suppresses to lower levels that even the shots. It is almost as if the value of 50 is a "mistake".....

But I remain more focused on the continued favorable PSA. We generally like to see T levels below 50 and sometimes we like to see lower (for example, <20 and <3) but the more important concept for me is the efficacy. If the PSA remains negligible, that suggest the cancer remains "starved" enough and remains in remission. If your T level was going up AND your PSA was going up, I would be more concerned.

At least that is how I analyze things.

Sincerely,

Paul Corn

[Tall_Allen in reply to 6357axbz]

Sometimes there is a lag between the time your T goes up and the PSA goes up.

[6357axbz in reply to Tall_Allen]

Any idea where Eleni Efstathiou is today and if she’s practicing PCa medicine?

[Tall_Allen in reply to 6357axbz]

No idea. Did she go to Greece?

[6357axbz in reply to Tall_Allen]

Don’t know. Couldn’t find doing google

[6357axbz in reply to Tall_Allen]

We all know that “resistance” occurs allowing PSA to rise even though T remains low due to ADT, BUT have you ever heard of ADT stop working, allowing T to rise back up?

[Tall_Allen in reply to 6357axbz]

I agree that it may be a bad lab report. Just retest.

[6357axbz in reply to Tall_Allen]

Retested this morning.Results: <10

Not the lowest it’s been but I don’t think it’s cause for alarm

[6357axbz]

😀