Dear all,
NCCN guidelines version 2.2021 – Prostate cancer, page 100 said “Abiraterone can be given at 250mg/day and administered following a low-fat breakfast, as an alternative to the dose of 1000 mg/day after an overnight fast”. Do any of you know if the practice of having 250mg Abiraterone/day is popular or not? Looking forward to hearing from you.
Thanks in advance for your sharing
Great ! Finally FDA is willing to tell it. .now that Zytiga is generic. Research a year ago showed that 250 mg of Abiraterone (zytiga) taken with high fat b reakfast works as well as Zytiga 1000 mg taken empty stomach.Many of the men on this forum do take or have taken ..250 mg Zytiga with high fat breakfast.
What would a breakfast need to consist of to get the maximum desired result?
I couldn't agree with you more, I've been taking 500 mg of Zytiga for a long time now, with a fried egg on toast, filled by yogurt. I wish I could get 250 mg, but here in France it's not available.
It just seems so obvious, that a slow release of this form of treatment is better than gulping copious amounts of water and then flushing it all away.
Take care LearnAll.
Phil
I've read your posts and know you've been using zytiga 500mg /day for 2 years. Please tell us if you have ever used the full dose? and if so, how long was that period?
Hello Dawn,
I can't say for sure, I have been with this particular oncologist for two years and I had decreased the dose before that. I am now past my third year mark. So my guess is at least a year or maybe less. I didn't keep a record, as I wasn't supposed to be doing it.
But the previous treatments didn't work, the PSA reduced and then went up again, the side effects were very bad.
I started at 152 PSA, since the the Zytiga and the injection and prednisone, the results have decreased steadily 0.039 now.
I don't feel bad either, just the usual stuff.
I hope that helps.
Phil
Thank you Lettuce for sharing. I understand when you took full dose, PSA firstly reduced but then increased again and side effects were bad. Is it correct?
Hello,
Sorry I don't think that I explained myself very well.
Before Zytiga I was having other treatment, these treatments failed, they reduced the PSA a little, then it always increased. The side effects were always bad.
When the treatment changed to Zytiga, I took the full dose, 1000 mg a day. I didn't have the bad side effects that I had on previous medication, the PSA started dropping. But I think after about 6 or 9 months I switched to 500 mg a day. My reason was because I had read about the long term damage such drugs can yield, also there had already been trials of taking Zytiga with food and the results, although early looked good.
I wrote a passage here sometime ago, " one size doesn't fit all " I felt that our treatments should be tapered to us individually if at all possible. I still do think that.
When I was diagnosed, which is about 5 years ago, the cancer had gone beyond the prostate, removal of the prostate wasn't an option, the doctors felt it was better to confine the cancer with drugs. Looking back I think that I had been ill for a while, but being me, I'd ignored all the symptoms, wrong thing to do, but I've been blessed this far.
I hope that this clears things a little better, I wish you and you family a nice Easter.
Phil
I see, thank you very much for responded, we wish you a nice Easter too
Now that abiraterone became available as a much lower cost generic, interest in eating with food faded. The uncertainty in dosing with food creates a problem.
What would the benefit be? I have so many side effects, not sure what it feels like to be without side effects. Which side effects would improve?
I started with Firmagon last July, and was put on Abi in August at the low dosage. I have been on 250 mg abiraterone from the start. In my case, with a relatively low fat breakfast of fruit juice, oatmeal with nonfat milk, and tea. My PSA after about 3 months was unmeasurable, and my T was 7. So the low dosage works. As an aside, I have read that it is supposed to be a low fat breakfast, not a high fat breakfast. My only fatty breakfast is on weekends with 2 eggs and buttered or jammed toast and juice and tea.
Thanks Rmarkley! It’s what I’m looking for. Can you share what was your PSA before taking Abi?
Here is the PSA data in tabular form:Date PSA Procedures
6/8/2020 32
8/12/2020 6.17 ADT started July 14, 2020
9/8/2020 0.58
9/30/2020 0.16
10/27/2020 <0.04
12/1/2020 <0.04
12/29/2020 <0.04
1/26/2021 <0.04
2/23/2021 <0.04
Here is the medication schedule:
Date Chemical Name Trade Name Dosage Procedure Duration
6/24/2020 Axumin Pet/CT Scan
6/26/2020 Bone Scan Whole Body
6/30/2020 Guardant360 blood draw
7/14/2020 degarelix Firmagon 2X120mg 2x3mL Initial Injection once
8/5/2020 Dexa Scan
8/11/2020 degarelix Firmagon 80 mg 4.0 mL 20mg/mL Injection every 28 days
8/11/2020 abiraterone acetate Zytiga 250 mg once daily with food continuously
8/11/2020 prednisone Prednisone 5 mg once daily with food continuously
8/29/2020 Covid-19 Test
9/1/2020 SpaceOAR insertion
9/8/2020 degarelix Firmagon 4.0 mL 20mg/mL Injection every 28 days
9/8/2020 denosumab Xgeva 120 mg Injection every 12 weeks
9/16/2020 Start Radiation
10/6/2020 degarelix Firmagon 4.0 mL 20mg/mL Injection every 28 days
10/13/2020 Finish Radiation
11/3/22020 degarelix Firmagon 4.0 mL 20mg/mL Injection every 28 days
12/1/2020 degarelix Firmagon 4.0 mL 20mg/mL Injection every 28 days
12/1/2020 denosumab Xgeva 120 mg Injection every 12 weeks
12/29/2020 degarelix Firmagon 4.0 mL 20mg/mL Injection every 28 days
1/26/2021 degarelix Firmagon 4.0 mL 20mg/mL Injection every 28 days
2/23/2021 degarelix Firmagon 4.0 mL 20mg/mL Injection every 28 days
2/23/2021 denosumab Xgeva 120 mg Injection every 12 weeks
Thank for detail sharing about your Psa and meds during treatment
Wins Homecoming King in my book
zytiga reduced to 1 pill a day
Zytiga 
ZYTIGA SEVERE FATIGUE EVERY DAY ALL DAY
PSA Dropped after 22 days of Zytiga
Zytiga
