NCCN guidelines version 2.2021 – Prostate cancer, page 100 said “Abiraterone can be given at 250mg/day and administered following a low-fat breakfast, as an alternative to the dose of 1000 mg/day after an overnight fast”. Do any of you know if the practice of having 250mg Abiraterone/day is popular or not? Looking forward to hearing from you.
Great ! Finally FDA is willing to tell it. .now that Zytiga is generic. Research a year ago showed that 250 mg of Abiraterone (zytiga) taken with high fat b reakfast works as well as Zytiga 1000 mg taken empty stomach.Many of the men on this forum do take or have taken ..250 mg Zytiga with high fat breakfast.
I couldn't agree with you more, I've been taking 500 mg of Zytiga for a long time now, with a fried egg on toast, filled by yogurt. I wish I could get 250 mg, but here in France it's not available.
It just seems so obvious, that a slow release of this form of treatment is better than gulping copious amounts of water and then flushing it all away.
I've read your posts and know you've been using zytiga 500mg /day for 2 years. Please tell us if you have ever used the full dose? and if so, how long was that period?
I can't say for sure, I have been with this particular oncologist for two years and I had decreased the dose before that. I am now past my third year mark. So my guess is at least a year or maybe less. I didn't keep a record, as I wasn't supposed to be doing it.
But the previous treatments didn't work, the PSA reduced and then went up again, the side effects were very bad.
I started at 152 PSA, since the the Zytiga and the injection and prednisone, the results have decreased steadily 0.039 now.
Thank you Lettuce for sharing. I understand when you took full dose, PSA firstly reduced but then increased again and side effects were bad. Is it correct?
Sorry I don't think that I explained myself very well.
Before Zytiga I was having other treatment, these treatments failed, they reduced the PSA a little, then it always increased. The side effects were always bad.
When the treatment changed to Zytiga, I took the full dose, 1000 mg a day. I didn't have the bad side effects that I had on previous medication, the PSA started dropping. But I think after about 6 or 9 months I switched to 500 mg a day. My reason was because I had read about the long term damage such drugs can yield, also there had already been trials of taking Zytiga with food and the results, although early looked good.
I wrote a passage here sometime ago, " one size doesn't fit all " I felt that our treatments should be tapered to us individually if at all possible. I still do think that.
When I was diagnosed, which is about 5 years ago, the cancer had gone beyond the prostate, removal of the prostate wasn't an option, the doctors felt it was better to confine the cancer with drugs. Looking back I think that I had been ill for a while, but being me, I'd ignored all the symptoms, wrong thing to do, but I've been blessed this far.
I hope that this clears things a little better, I wish you and you family a nice Easter.
Now that abiraterone became available as a much lower cost generic, interest in eating with food faded. The uncertainty in dosing with food creates a problem.
I started with Firmagon last July, and was put on Abi in August at the low dosage. I have been on 250 mg abiraterone from the start. In my case, with a relatively low fat breakfast of fruit juice, oatmeal with nonfat milk, and tea. My PSA after about 3 months was unmeasurable, and my T was 7. So the low dosage works. As an aside, I have read that it is supposed to be a low fat breakfast, not a high fat breakfast. My only fatty breakfast is on weekends with 2 eggs and buttered or jammed toast and juice and tea.
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