Docetaxel vs. Cabazitaxel--effectiven... - Advanced Prostate...

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Docetaxel vs. Cabazitaxel--effectiveness?

WildRose6 profile image
11 Replies

Hi everyone,

Hubby just finished second round of docetaxel on Dec. 31st. Last year he tried both Abiraterone and Xtandi but PSA is still rising, even after docetaxel. MO wants him to try cabazitaxel next.

My question is, is there really that much difference in effect on the cancer? If he's progressing after docetaxel what are the chances cabazitaxel will help? He's really reluctant to do more chemo as he has a lot of nausea and vomiting.

Anyone here had success with cabazitaxel after failure of docetaxel?

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WildRose6
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Tall_Allen profile image
Tall_Allen

That's exactly the situation that Jevtana was approved for - it works when Taxotere fails.

thelancet.com/journals/lanc...

Some find the side effects easier.

clinical-genitourinary-canc...

Consider adding carboplatin too.

ncbi.nlm.nih.gov/pmc/articl...

Brackenridge profile image
Brackenridge in reply to Tall_Allen

Thank you Tall_Allen! I’m not smart like you so its okay that I just try to read and absorb the Lancet summary without paying for the full report which I’ll NEVER in a million years understand?

Tall_Allen profile image
Tall_Allen in reply to Brackenridge

That'll give you the gist. Cabazitaxel was designed to work after docetaxel failed. That's exactly what it was approved for.

Brackenridge profile image
Brackenridge in reply to Tall_Allen

Thank you!!!!!! And Happy Valentines’ Day!

Many have said that Cabazitaxel was easier for them to tolerate than Docetaxel. Cabazitaxel is less likely to cause neuropathy, but is more liley to suppress the bone marrow so you have to watch out for neutropenia. It is effective in many cases where Docetaxel becomes ineffective.

Here's one article about Cabazitaxel:

ncbi.nlm.nih.gov/pmc/articl...

From the article:

Conclusion

The clinical development of cabazitaxel has provided an important proof of principle that targeted therapy to overcome a specifically identified mechanism of resistance in the treatment of mCRPC is possible. In this case, a novel taxane was demonstrated to have clinical activity in docetaxel-resistant mCRPC. Given that mCRPC remains incurable, even with the advent of multiple new therapies, each approved drug will have a place in both extending survival and improving patient quality of life. Cabazitaxel represents a therapeutic option for men with metastatic CRPC whose condition has progressed on docetaxel and is associated with a survival advantage.

WildRose6 profile image
WildRose6 in reply to

Thank you Gregg. I hadn't seen that article yet. Hubby has some neuropathy from the docetaxel but his bone marrow is still good. He's dreading more chemo but if it can knock things back a bit... well, that's the crazy game we're all playing, isn't it?

in reply to WildRose6

I certainly understand the calculation that has to be made regarding treatments.

The good thing with the chemotherapy is that he can bail out at any time so he just has to commit to one cycle at a time.

What I have found to be helpful for me, especially in the most difficult times is to just put one foot in front of the other. Just one treatment at a time. I would try not to think about "chemotherapy" as a whole, but just the one cycle that was in front of me. That makes it much less overwhelming in my experience.

WildRose6 profile image
WildRose6 in reply to

"Just one treatment at a time"

So true, thank you for the reminder 🙏

Brackenridge profile image
Brackenridge in reply to WildRose6

My Dad just had his 10th “half one treatment at a time” yesterday 🤞🏻🤞🏻🤞🏻

Brackenridge profile image
Brackenridge in reply to WildRose6

Sadly yes it is. My heart is with you.

Godschild62 profile image
Godschild62

My husband was on his death bed when he started cabazitaxel.. he responded so well he, was golfing again. Unfortunately his cancer was so aggressive, it didn't last long before it stopped working (about 6 rounds).

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