Thymoquinone (found in negella sativa and monarda fistulosa plants) may target some castration resistant and/or metastatic prostate cancers

[Graham49]

Article

Published: 21 July 2020

Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion

Susumu Kohno, Paing Linn, Naoko Nagatani, Yoshihiro Watanabe, Sharad Kumar, Tomoyoshi Soga & Chiaki Takahashi

Oncogene volume 39, pages5690–5707(2020)Cite this article

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Abstract

RB1 gene is often homozygously deleted or mutated in prostate adenocarcinomas following acquirement of castration resistance and/or metastatic ability. We found that SUCLA2 gene is frequently involved in the deletion of the RB1 gene region in advanced prostate cancer. SUCLA2 constitutes the β-subunit of succinate CoA ligase heterodimer that reversibly converts succinyl CoA into succinate. We sought the possibility that deletion of SUCLA2 gives rise to a metabolic vulnerability that could be targeted therapeutically. We found a significant metabolic shift in SUCLA2-deleted prostate cancer cells, including lower mitochondrial respiratory activity. By screening a number of libraries for compounds that induce cell death selectively in SUCLA2-deficient prostate cancer cells, we identified thymoquinone (2-isopropyl-5-methylbenzo-1,4-quinone) and PMA (phorbol-12-myristate-13-acetate) from a natural compound library. These findings indicate that the metabolic vulnerability in SUCLA2-deficient prostate cancer cells is pharmacologically targetable.

[Mascouche]

Interesting but it is Nigella sativa, not Negella sativa for those who might search for it.

[Graham49 in reply to Mascouche]

Agreed, just a typo.

[dhccpa]

How much are you taking daily? Thanks

[hadleycash]

What brand and dosage do you use Nal? Thanks!

[podsart]

Do you take black seed oil because you have this mutation:

“These findings indicate that the metabolic vulnerability in SUCLA2-deficient prostate cancer cells is pharmacologically targetable.”

[podsart]

Thanks

[Mascouche]

I've begun to take Nigella Sativa and it tastes like used motor oil. Even putting a teaspoon of it in a whole glass of homemade green juice is not enough to hide the taste. What do you take it with?

[Mascouche]

Capsules were probably a smarter choice than the oil I purchased.

[GeorgeGlass]

what brand do you take Nal? I noticed my bottle of oil has been in the back of the cabinet for 1.5 years, only 1/5 used. I think I will buy pills. Thinking about the Life Extension brand.

[GeorgeGlass]

Your anti estrogen position makes me believe that you would not be a supporter of the estrogen patch. Is that true? I’ve been wondering if someone could extend the life of castration sensitivity by doing the patch for awhile and then switching back to Lipton etc. What do you think of that idea?

[GeorgeGlass]

OK, thanks Nal, I'll check it out. George

[cigafred]

By "not available" are you referring to commercially, biologically, or something else?