I wonder what you all make of this?
sciencedirect.com/science/a....
“A rise of intracellular Ca2 + concentrations is also required for efficient CTL and NK cell function and thus for killing their targets
…. In general, transient small elevations (low to medium nM) of cytosolic Ca2 + will increase cell proliferation whereas sustained substantial elevations (high nM to μM) may induce apoptosis”
academic.oup.com/endo/artic...
“both testosterone and nandrolone produce rapid intracellular Ca2+ transients involving Ca2+ release from inositol 1,4,5-trisphosphate (IP3)-sensitive stores”
What I am gathering is that testosterone causes calcium ion influx. If the calcium ion influx is low then it helps PCa grow. If it is high it kills PCa via apoptosis. Possibly one of the reasons that low/medium T is suspected to be a negative for PCa patients yet high T might be a positive (Huggins et al).