Does anyone have enough background to tell me if this looks like something similar to fenbendazole and/or mebendazole?
VERU-111 is an oral, next-generation, first-in-class selective small molecule that targets and binds to the alpha and beta-tubulin subunits of microtubules in cells. Microtubules are essential components for cell division and for shuttling critical growth receptors into the nucleus, where they stimulate cell proliferation. Unlike taxane chemotherapy, which only binds the beta subunit of tubulin, VERU-111 binds strongly to both the alpha and beta-tubulin subunits. Additionally, VERU-111 inactivates by cleaving poly ADP ribose polymerase (PARP), which is important for DNA repair in cancer cells.
No, not at all similar. It's more similar to taxanes (docetaxel, cabazitaxel) in that it stabilizes microtubules so that the cancer cell cannot divide. It also acts as a PARP inhibitor. It is a kind of chemo.
Thanks, and this is neither important nor aimed at boosting fenbendazole, but I thought that the presumed activity of fenbendazole was to do the same. At first check I cannot find an authoritative source, but there are many references like this: "Fenbendazole is in a class of medications called benzimidazoles, and the main action of these drugs is to inhibit tubulin polymerization. Drugs that inhibit tubulin polymerization are sometimes called microtubule inhibitors and are some of the most frequently used anti-cancer drugs. Taxane-based drugs and vinca alkaloid-based drugs are both examples of chemotherapy drugs that are microtubule inhibitors. Microtubules are like little ropes that are used to move things around the inside of a cell. They are especially important during cell division (aka. mitosis) when they move and separate chromosomes (genetic material) before it can be replicated. If a medication prevents microtubules from doing their job correctly, cell replication can’t be completed, and the cell will die. In cancer medicine, these drugs are used because cancer cells typically reproduce and divide faster than healthy cells."
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Duration of ADT
we will soon know more about Nubeqa
Veru Reports Positive Clinical Results from VERU-111 Phase 1b/2 Trial in Men with Metastatic Castration-Resistant Prostate Cancer, Advancing
