Dexamethasone+abiraterone along with lu psma treatment

[Vsahay]

Due to covid 19,we have decided to postpone my dad's 2nd lu psma treatment.The first cycle was administered on 26th feb.He is currently continuing abiraterone +prednisone combo.His psa has been rising since july.Is it a good idea to switch to dexamethasone (with abiraterone)until we are able to travel to get him the next cycle of lu psma treatment?

Would delaying the lu psma treatment reduce the efficiency of upcoming cycles?

[GP24]

You can try switching to Dexamethasone. The dose is 0,5 mg once per day.

If you extend the time between cycles, the Lu PSMA treatment has more cancer to fight against. This cancer had grown in the meantime. I do not think this is a problem.

[Hope59]

My husband switched from Prednisone to Dexamethasone. He is taking 0.5mg TWICE a day with breakfast and after lunch. It brought his PSA down for a few months then it began to rise again a little. Our MO switched him to squeeze more time out of the Zytiga. It's worth a try.

[Hidden]

I've gotten 6 months so far out of the switch since my PSA started rising. It's back down to undetectable.

[ctflatlander in reply to Hidden]

I have seen a slight PSA uptic (.3 to.49) since the switch to Dexamethasone. The last PSA test was my first ultra sensitive one. Mo wants to see my results of the next test in 3 weeks.

[j-o-h-n]

My only "open" question to you is when do we decide #19 is over.... or will it become #20?

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 08/11/2020 7:00 PM DST

[immunity1]

As much of this therapy is in its early days, intervals between treatments have not been standardised. In 2017 I had an interval of 2 months between 4 treatments, but more recently here in NZ I have had an interval of 6 weeks. My feeling is that it is best not to delay the treatment as it is more effective against micrometastases because of the limited penetration of beta particles. Sorry about your Covid 19 dilemma. Rob.

[utkarsh_1996]

Alot of problems were faced by cancer patients in this pandemic

youtube.com/watch?v=SvDkujp...(Not working as expected?)

this might help for what precautions and protocols we should follow

Hope everything goes well.

[Vsahay in reply to utkarsh_1996]

Thanks☺