Discussion of Phase 2 trial with LU-177 PSMA-617

I saw this presentation of the results of a phase 2 trial with LU-177 PSMA-617 and thought it was well done. I thought this presentation could be helpful to those who are new to this or would just like to know more about the LU-177 treatment.

We'll all know a lot more about LU-177 when we get the results of the VISION trial.

urotoday.com/video-lectures...

[Walkingwell]

Useful, thank you.

[j-o-h-n]

Thank you gregg...for your vision......

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 05/18/2020 9:20 PM DST

[Shanti1]

Really informative video, thanks for sharing.

[TheTopBanana]

Hello, perhaps a stupid question but what is the difference between Lu 177 and Ac 225? In terms of outcome, well anything really.

[Hidden in reply to TheTopBanana]

The main difference between the two is LU-177 is a beta emitter and AC-255 is an alpha emitter. Beta particles have much less mass and travel further, doing less damage to the cancer cells. Alpha particles are high energy and short range, ideal for destroying whatever cancer is in their range with double strand DNA breaks. The problem with AC-225 is that the side effects are worse because the salivary glands also put out PSMA so it goes there too. Some centers are using a combination of the two.

[TheTopBanana in reply to Hidden]

Thank you!!

[Hidden]

Is this something that will available eventually to hormone sensitive?