My husband has been on Lupron for 8 years and is becoming resistant as his PSA keeps rising.
Oncol. now wants to add xtandi to his treatment plan.
Haven't been on this site lately to know what is current protocol or next step.
Can anyone offer suggestions.
Hope all is well with this virus and otherwise.
BOOGIE
Zytiga, Xtandi, or docetaxel are all good next steps.
Thanks TA,
Added Xtandi during chemo and drove PSA to 0.08. Side effects made me a complete invalid on 160 mg dose. After several cuts ended up on half dose which I am still taking.
The photo looks like he’s wearing the crown of the Crab King . May the Xtandi work well and bring that psa back dow again . 8 years clear is very good . We that wait in the eye of this storm with an undetectable psa all know that a rise is projected for us all at some point . Good that you have each other.. Thank you Scott
Hi WP,
Yes he is wearing a King Crab hat.
Dr. thinks this will work, but concerned with taking it and still getting Lupron injections. Just want him to have a fair quality of life.
Stay strong
BOOGIE
On Lupron for about 2yrs. Added Xtandi 1 1/2 months ago. NO additional side effects noticed yet. Dropped PSA from 9.1 and climbing down to 1.7 already. Better than expected. Started at 1303 and climbing a point a day 2yrs ago. 1.2 lowest around 6mo later.
I'm thrilled with Xtandi right now.
2Dee
How long have u been on the xtandi?
Thank u
Olivia,
He hasn't started Xtandi yet.
Will within this next month.
BOOGEE
8 yrs is amazing what would the average be for Lupron, it looks like my Zoladex has stopped working so I am looking for a good option for next treatment either Lupron or Xtandi.
Hi Chubby,
Perhaps Tall Allen or someone else may chime in and answer that question, but Oncol. said he had a great run on Lupron.
She say adding Xtandi will buy another year on average.
Well wishes with your treatment.
BOOGEE
I thought that I read that Lupron averaged 19 months, and Enzalutamide(Xtandi) averages 29 months. I am nmcrpc and I am just now transitioning to Enzalutamide after being on and off Lupron since 7/17. RRP in 11/16 followed by radiation with Lupron in 7/17. Interestingly, the paperwork with the Enzalutamide suggests taking it with Lupron, which has stopped working for me and my ONC hasn't suggested.
8 years on Lupron is a good run. I would ask the oncologist about casodex instead of xtandi. It's an older milder ADT drug. If and when casodex fails zytiga would be the next step. I was on casodex for 5 years.
Hi Magnus,
He was on Casodex along with Lupron for the first few years of treatment.
Zytiga vs. Xtandi?
If Xtandi fails can he transition over to Zytiga will be the next question we will ask oncol.
Hang in there
BOOGEE
Hey ROLNCIN1!
Dr. Laurence Klotz recently oversaw a study funded on the effects of capsaicin on prostate cancer. pjoshea13 was kind enough to post the link to the study in December of last year. I saved the link but the study itself no longer loads but a synopsis of sorts. Perhaps pjoshea13 could be of assistance in recovering the study. From memory, the men were given 40,000 heat unit capsules of capsaicin in the AM and PM. The results found that cancer stem cells were killed.
Below is the link pjoshea13 posted:
ncbi.nlm.nih.gov/pubmed/317...
An interesting PDF--copy the entire print between the lines:
_____________________________________________________________________________
Capsaicin as a Novel Chemopreventive and Therapeutic ...
tspace.library.utoronto.ca/......
______________________________________________________________________________
An excerpt from page 50 of this PDF.
"Results: Capsaicin exhibited anti-proliferative and pro-apoptotic effects, which were
significantly enhanced with the addition of lycopene in PCa cell lines. The greatest effects were
observed in androgen-sensitive cell lines. Detailed mechanistic studies revealed this combination
may be interrupting the androgen-signaling pathways; independent of TRP-V1 signaling. Cell
cycle analysis revealed that capsaicin and lycopene induce a cell cycle arrest, corresponding to
alterations in tumour-suppressor proteins. Treating LNCaP cells with capsaicin and lycopene
also altered proteins involved the apoptosis signaling pathway including, cleaved PARP,
Caspase-3 and Bax/Bcl-xL expression.
Conclusions: Our results suggest that lycopene enhances the anti-cancer properties of capsaicin.
Understanding micronutrients interactions may help improve current chemoprevention strategies. "
At the 14 minutes and 30 seconds Dr. Klotz discusses a patient whose prostate cancer has become hormone resistant. I think you will find this to be interesting.
Dr. Greger relates the results of an interesting study funded by a non profit involving, pomegranate, green tea, curcumin and broccoli supplements. Ever heard of Pomi-T? Funding ended at 6 months, therefore, no other supplements were added to see if even better results could be obtained. I would think Kyolic Immune Formula 103, a resveratrol, quercetin, ginger and maitake mushroom and PSK or Turkey Tail mushroom would be good additions to the four supplements in the study. A little about PSK--the Japanese have been prescribing PSK to patients receiving chemo to strengthen their immune system. I'll leave it at that as you mat wish to use your search bar.
Below is the YouTube video where Dr. Greger discusses the power that synergy has when using natural substances.
As always, keep all your doctors informed about the supplements that you take so as not to interfere with any treatments or medications.
I wish you the best,
Currumpaw
I've been on Abiraterone Acetate (Zytiga) since 10/22/18, which has given me 20 months of second level protection against testosterone in my system. When I asked a Physician's Assistant if I would be prescribed Xtandi when I eventually fail on Zytiga, she told me, "We won't put you on that drug. It's too similar to Zytiga. If you fail on one, you'll almost immediately fail on the other." Does anyone else on this forum have information that contradicts that opinion?
Many guys have an excellent response to Xtandi, myself included. After a couple years on Eligard (Lupron) and Firmagon, I started becoming resistant with rapidly doubling PSA. We added Xtandi to the mix and my PSA dropped to undetectable almost immediately. I took Xtandi for about 10 months before having to stop all ADT due to heart complications. I have been on my ADT "vacation" since last November, and my PSA, while starting to creep up, is still undetectable at .04
Xtandi is a good next step... I couldn't handle 160 mg, or 120 mg, so been on 80 mg (half the full dose) and it is working fine...
Thank you Braveheart,
Our Oncol. agreed we can try 1 of the 4 pills prescribed to start.
We can add if needed.
BOOGEE
recurrence after prostrate removal 5 mos earlier. Lupron monthly now every 6 mos, 30 days on xtandi no major side effects.
Xtandi/ UTI with Foley/ low hemoglobin 
xtandi 
Xtandi and Increasing PSA
Xtandi vs Orgovyx
