I have been on Xtandi for two weeks now..Take the big four every night. I have been on Lupron for two years. Other than waking up a few times a night with a little hot flash feeling really good. The first dose of Xtandi I took in the am and immediately felt a little blah on and off for a few hours but was working outside and by afternoon I felt fine.. I switched to night time and now no problems...Is there a lag in side effects?