I'm curious if anyone has seen information on whether or not a younger man with aggressive stage 4 PCa is in more peril than say a 75 year old under similar circumstances. Commonsense would lead me to believe that it would be since the cancer has formed earlier and is growing and mutating much more quickly, but I have yet to see any studies on the topic. My docs are hitting me with Lupron/Zytiga, Provenge, SBRT to the bone mets, Xgeva, and eventually Docetaxel and Xofigo.
Is stage 4 in a 57 year old more dang... - Advanced Prostate...
Is stage 4 in a 57 year old more dangerous than in an older man?
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V10fanatic
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47 Replies
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Every prostate cancer is different so evaluating your particular cancer is much more specific than general trends in populations.
There was a large retrospective study for men who had local treatment with prostatectomy that found older men had more aggressive prostate cancer.
The more aggressive prostate cancers with genetic variants do often appear earlier so that can give the impression that younger people get more aggressive prostate cancer. Many times these are inherited.
europepmc.org/article/med/3...
• in reply to
Yes , mine was .
All the studies that I have read indicate that this is not the case. Early stages of prostate cancer could possibly take a less aggressive course in those who are older, but things like treatment efficacy on survival appear to be the same.
I had similar questions over five years ago at 53 with stage #4 non-op , gl 8 t-4 an aggressive APC . My specialist told me that “ we don’t often see this so advanced at such an early age” he said” because of this you’ll never see 80 and you WILL die of prostate cancer “ . Stage 4 no cure .. everything that we do is to extend our time here. A year later after imrt and double adt I went into remission . That same specialist told me” you’ve got 30 years left”
He was so happy , so was i .. reality is I’ll be very lucky to get five more years . Being younger might give us a little more strength to get us through treatments. But if you didn’t feel old before, you will now . Try to maintain bone and heart health . Both weakened greatly by treatments. We all carry this with us to the end if something else doesn’t get us first like a heart attack. My theory is that with the older guys most have suffered something by 70 and they are some what tuffened up and grizzled up by then . I was never sick and had no chronic illness prior to APC getting me . I took my fall from grace hard . Suffered self loathing and poor me why me? At some point we adjust if we are so lucky . Live in the present. Enjoy what you can . Be well TGIF ... Scott
Haniff• in reply to
If you would write a Motivational piece, it would be right up there with the best. Well said Bro 👌
Yup, enjoy the Present before the rug is pulled out from underneath us 😉
Take care and this is a plea to all my good brothers, stop looking into the crystal ball, Life is wonderful, cherish it ❤️
Haniff
WVtwinsmama• in reply to
My husband was 52 when diagnosed with a G9, stage 4, Mets to bone, PSA NEARLY 1,000. That was 2 years ago. Doing pretty well at the moment after Docetaxel, Zytiga, Xofigo, Xtandi and some RT. Getting new labs Tuesday and expect to get new CT and Bone Scan soon to see how Xofigo fared. Approved to try Lynparza if we can get his blood counts up. His PSA started to rise after Xofigo. Not sure if it was the Xofigo or disease progression.
• in reply toWVtwinsmama
Wow 1000? 52 I was 53 ..It is incredible what we can live with . I’ll will wait to hear the new labs. ? Thank you for sharing . It helps others . Be well & take care 🌵😷
ck722• in reply to
Just wondering, were you exposed to trichloroethylene?
In general, older men have more aggressive prostate cancer than younger men. However, I think you're right that younger men with aggressive prostate cancer require very aggressive treatment.
ncbi.nlm.nih.gov/pmc/articl...
auajournals.org/article/S00...
• in reply toTall_Allen
That’s for sure .
My partner certainly did - everything bar the kitchen sink!!! His PSA is undetectable 7 months after chemo stopped - hope it stays this way. Still getting hot flushes and no testosterone even though he on'y had 2 ADT injections and last one was 10 months ago...
The only peril is see is I probably won't make it to 80 having started this journey at 54 instead of 74. Can't worry about that living each day best I can. Good luck and stay vigilant.
I was diagnosed in 2016 with Gleason 5 + 4 and had RP T2cN1. I was given chemo and ADT as post surgical treatment, which in some respect is because a younger, otherwise healthy man, can take the more aggressive treatments with less harmful side effects. I also believe it can be a more aggressive version.
Good luck.
• in reply todmt1121
I agree.
I was diagnosed at 47 with stage 4 Prostate cancer. My initial PSA was1882 and I had it in most of my lymph system and most all bones. Now 5 years later my PSA is around .1, no uptake in my bones and lymph system. I feel pretty good and my doc says I will probably die of something other than Prostate cancer. Good luck with your journey- keep a positive attitude, eat well and enjoy life.
Hopefully from a jealous wife or jealous husband.
Good Luck, Good Health and Good Humor.
j-o-h-n Saturday 06/27/2020 6:24 PM DST
Marco, well done.
How did you get the beast out of your bones?
I am not really sure if it is gone, we are trying to keep it from growing and my doc says my bones will try to heal themselves. I think the Xgeva and the calcium add in that. I have not had a PETSCAN in over a year, but my last one came back with no uptake in my bones. So I think what we are doing is working. I consider myself to be very lucky. I try not to think about what I have and try to live like a normal person. Hope all is well with you and I hope I answered your question. I am here if you have more.
I just turned 56...
At 36 years old I was diagnosed with Stage 3 colon cancer...surgery and chemo fixed that problem.
At 42, I was diagnosed with melanoma...surgery fixed that.
At 53, I was diagnosed with both renal cancer and stage 4 prostate cancer...renal fixed with surgery and prostate removed, radiated, ADT, Erleada, doceltaxol, Provenge on deck (at the end of July), and I’m told Darolutimide after that.
At 55, I was diagnosed with CLL...watch and wait (the equivalence to a common cold when compared to prostate cancer)
Weight in check, diet is good, exercise.
I plan to make it to 90...to many things left to do 
• in reply to
I can’t even equate what you’ve been through to my poultry one cancer . You’re amazing dude. Keep truckin what an attitude. Bad ass! 💪
• in reply to
Lol...I guess I’m too stupid or stubborn to let the cancer control my life.
• in reply to
The will to live can be a strong force brother. We all need it to survive with this . 😎
Haniff• in reply to
Oh wow Brother, you’re my new poster boy ❤️
Keep up the good fight, my Knight 🥇
Haniff
• in reply toHaniff
😂😂😂👏🏼
• in reply toHaniff
Thank you! My knights armor has a few dents in it for sure. At least when I’m shirtless at the pool, my torso looks like I’ve been in a knife fight. Those surgeons really cut me up good...but it does look like I’ve been in a few ugly battles
Haniff• in reply to
😆😆😍
• in reply to
Tell the grandkids it was a shark attack! 😂
• in reply to
I love that!!!!
• in reply to
So will they😂😷
As one who was metastatic at age 57 and currently age 73, I suggest that you hit it hard and aggressive while your body is strong and the tumor burden minimal. Multi-modal approach. Kill the unseen bastards as they are the ones that will rear up and grow years from now.
Gourd Dancer
• in reply to
Those bastardos !
MarcoGlenn• in reply to
Can you provide a little more detail. I am basically watching my PSA. Is there something else we should be looking for specially what you mean by the “unseen bastards”? Thanks.
• in reply toMarcoGlenn
Marco, I am referring to micro-metastasis. It explains primary treatment failure. It is excellent conversation to have with your Doctor.
GD
MarcoGlenn• in reply to
Thank you I will look into it.
Kill the seen ones too............
Good Luck, GoodHealth and Good Humor.
j-o-h-n Saturday 06/27/2020 6:28 PM DST
• in reply toj-o-h-n
Off with their heads!
I have been asking myself the same question.
But I have noticed that there are few answers as to what to expect.
Each case is different. (This both scares and gives hope).
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