Veru Initiates Phase 2 Clinical Trial of VERU-111, First-in-Class, Oral, Advanced Prostate Cancer Drug

[JLS1]

Anyone in this trial? It sounds promising. Someone posted earlier that this drug, being a tubulin inhibitor, is very similar to fenbendazole, which anyone can buy OTC (but if I remember correctly, earlier discussion here concluded it's not bioavailable for humans, so no good?? - think UC David may have a formula in trial).

verupharma.com/news/veru-in...

verupharma.com/pipeline/ver...

clinicaltrials.gov/ct2/show...

Sounds safe, even for those with very low blood counts:

"In preclinical effectiveness and toxicity studies, orally administered VERU-111 demonstrated significant antitumor activity against castration and novel androgen blocking agent (abiraterone or enzalutamide) resistant human prostate cancer models. Furthermore, VERU-111 had significant antitumor effects against cancers that overexpress multidrug resistant proteins, like P-glycoprotein, a common mechanism by which cancer cells become resistant to cancer drugs. At oral doses that had significant antitumor effects, VERU-111 had a favorable safety profile as it did not cause neutropenia or myelosuppression, common dose limiting side effects of other classes of commercially available antitubulins such as intravenous taxanes or intravenous vinca alkaloids. In addition to prostate cancer, VERU-111 had antitumor effects in other cancer types including preclinical human models for triple negative breast cancer, ovarian cancer and pancreatic cancer that are sensitive and resistant to taxanes. VERU-111 has the potential to be the first FDA approved oral, selective antitubulin agent that targets and disrupts alpha and beta tubulin subunits of microtubules to treat cancer."

[Amandaslp78]

We were hoping to get into this trial at Johns Hopkins and went through the process, however my dad‘s blood count, hemoglobin was too low to get in. He was an 8 and it needed to be a 9. 😢