Thank you Rooked!!! for posting about using Cabergoline for treatingTerminal Androgen-independent Prostate Cancer!!! I did a quick search and found several very recent, VERY encouraging articles. So why hasn't this been made more public??!!!
For those who didn't see Rooked's post, here's a link to what he posted:
A Novel Patient Case Report to Show the Successful Termination of Untreatable Androgen-independent Prostate Cancer: Treatment with Cabergoline (Dopamine agonist).
A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How?
Been trying to send my responses but for some reason it’s kicking back. I don’t see anything for 2019 or 2020. I don’t want to get my hopes up and I am a little cynical wondering what’s the catch thoughts?
Been trying to send my responses but for some reason it’s kicking back. I don’t see anything for 2019 or 2020. I don’t want to get my hopes up and I am a little cynical wondering what’s the catch thoughts?
The article also mentions using zinc (zinc 50mg per day) and a cream that was discontinued by the FDA but can be ordered by doctor that inhibits copper to help shrink the tumors. Good luck.
Do you have any thoughts on why we can’t find anything else about a A drug combination that ends the report saying that it can terminate metastatic castrate resistant prostate cancer.
FYI, I am in Maryland and I am trying to write a note to the scientist that wrote the report. He is a physician at the University of Maryland. I will let you know!
Do you have any thoughts on why we can’t find anything else about a A drug combination that ends the report saying that it can terminate metastatic castrate resistant prostate cancer.
FYI, I am in Maryland and I am trying to write a note to the scientist that wrote the report. He is a physician at the University of Maryland. I will let you know!
The problem is cancer is heterogeneous. That means every person is different and will respond differently to treatment. Also many doctors follow cookie cutter guidelines and have no insight especially cancer. The problem is everyone is different and will respond differently.
I had to go on a google scholar search to find this obscure article.
Fellow travelers, that report is about a single individual. It is not a trial result and, when I last looked, there are no clinical trials involving cabergoline. I'd like to know, "why not?"
They’ve had trials with anti prolactin medications like bromocriptine and Cabergoline, zinc supplementation, and copper supplementation. But all were separately and not combined. With cancer, many posts need to be combined to effectively fight the tumors. regardless, tell your MO to try this if all other options are off the table.
They’ve done trials with another prolactin inhabiting substances in the past with bromocriptine that has not worked for other cancers. This article deals with a combination of inhibiting prolactin, using a copper chelating cream that is FDA discontinued, and OTC zinc supplementation.
I wish there were trials to standardize the care regarding this therapy, if it ends up being effective for many people.
Your search returned just 7 results while hypothesis with substance can return hundreds. Out of these seven, only three support the hypothesis are written by the same guy who is an author of this idea. Two articles are based on the case of one (1) patient only.
Next three have a weak relevance and/or are inconclusive. And the last one, the only real prospective study, found that high levels of prolactin don't cause prostate hypertrophy in young men.
Like I said cancer is heterogeneous and treatments will vary from person to person. However, it seems that prostate cancer at least thrives on hormones. When testosterone, a product from androgen, is no longer stopping working, then a substitute hormone may allow growth in its place. When the back is against the wall, Stopping prolactin and copper while adding zinc may help shrink the tumor. At least give it a chance.
If there is another answer please post it and help us all.
There may need to be a drug holiday like intermittent androgen deprivation therapy to allow normalization of zinc and copper blood levels
Either way clinical trials or a prospective cohort study should be performed to see if a regimen can work with as little or no adverse effects and be effective for a larger sample size.
I learned about cabergoline (trade name = Dostinex) after reading Stephen Strum's book, Prostate Cancer: Essential Concepts for Survival. I believe this is an excellent read and I recommend it highly to guys with PCa and especially those on ADT. Strum recommends cabergoline (or bromocriptine, another similar drug) because they both inhibit prolactin. He lists 8 reasons why it's important to inhibit prolactin in men with PCa. These include improving libido, decreasing angiogenesis, increasing cognitive function and decreasing testosterone uptake in prostate cancer cells. Dr. Snuffy Myers also recommends its use.
I spoke to my oncologist at MSK and asked if he could prescribe it for me, but he said he wasn't comfortable doing that because it wasn't considered well-established therapy for PCa. I was disappointed with that opinion, so I'm very interested to know how you do on cabergoline, Contrailbob, so please keep us updated on your experience. Thank you!
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