PectaSol (modified citrus pectin)

[pjoshea13]

Press release [1]:

"SANTA ROSA, Calif., Jan. 2, 2020 /PRNewswire/ -- Better Health Publishing—A multi-center Phase IIb clinical trial conducted in Israel, has been studying the effects of a dietary supplement, modified citrus pectin (PectaSol®, Econugenics, Santa Rosa, California) in prostate cancer patients who underwent local treatment for prostate cancer and subsequently experienced a non-metastatic biochemical relapse of the cancer. Results of long-term 18 months treatment with MCP demonstrate continued benefit from the use of MCP, with significant improvement against prostate cancer.

"Interim six months results on 45 patients were initially presented at the ASCO-GU (American Society of Clinical Oncology-Genitourinary) Annual Cancer Symposium in San Francisco, CA, in February 2018. These results demonstrated the ability of MCP to slow PSA doubling time (PSADT). PSADT is an accurate measurement for recurrent prostate cancer growth in patients whose prostate has been treated with surgery and/or radiation. Of the 45 patients enrolled at the six-month evaluation, 68% (n=31) showed reduction in disease progression.

"Updated results following an additional 12 months of treatment with MCP were recently published in European Urology Supplements and presented at the 11th European Multidisciplinary Congress on Urological Cancers—EMUC19, in Vienna, Austria, November 2019. This extended arm of the study followed the 31 patients who successfully completed the first six months of the trial, to further evaluate the long-term effects of MCP treatment at 5 grams/three times daily. These results showed that 65% of subjects had no disease progression. There was no treatment interruption due to adverse effects. 50% of subjects had a lower PSA, or PSADT lengthening at 18 months, compared to their baseline 18 months prior. Currently, the 60 patients planned for the study have completed the initial 6 months with promising results, and all the patients who showed benefit are continuing for an additional 12 months.

""This study confirmed results seen in two previous, smaller studies," says Dr. Daniel Keizman, the principle investigator of the study. "The interim results of the 18 months long-term follow up, are demonstrating the potential of this specific MCP to benefit prostate cancer patients with biochemical relapse for long periods of time."

""These results, coupled with the safety of MCP, warrant larger control double-blind clinical trials to optimize its use in prostate cancer patients, and possibly in other cancers," says co-investigator, Dr. Isaac Eliaz."

...

Not that Eliaz owns the product & participated in the study.

See also [2].

-Patrick

[1] markets.businessinsider.com...

[2] curetoday.com/articles/diet...

[GreenStreet]

Thanks Patrick. What’s your feeling about it? I have been taking the product for a few months but next PSA test is not until March. The product is not cheap and I wonder whether it will go up more as a result of this. On the other hand seems quite encouraging notwithstanding the obvious limitations which in fairness they seem to recognise

[pjoshea13 in reply to GreenStreet]

I have never met Eliaz (I know some have consulted him), but I take against him because his products seem arbitrarily expensive to me. In one form or another it has been around for 25 years.

I'm also wary of studies where the owner of the product is on the team.

But I do have the product because I feel that it may be incrementally beneficial for me. It's not in my top 5, but I do use it - when I remember.

-Patrick

[GreenStreet in reply to pjoshea13]

Thanks for the post and your views. I will keep with it. I sometimes take the tablets for the middle doze of the day if working or travelling because the powder form is quite difficult unless you buy and decant into a different container. Expensive but if there is a chance of positive action worth it.

[cigafred]

Thank you sir. Now I must go back to my notes to figure out how many grams in a scoop.

[cigafred in reply to cigafred]

I now see on the label it says 1 scoop = 5 grams approx.

[AnnieAppleseed]

I first heard of this in the 1990's when I was diagnosed with breast cancer. Dr. Eliaz has spoken at conferences my nonprofit Annie Appleseed Project organizes. I took the product with the idea that a hormonal cancer might benefit. I know because of my 25 years of Advocacy that FDA has yet to approve a non-patented substance. So the trials continue to be phase II with no end in sight. This should go to phase III at once. I hope it does someday but I don't expect much. I also wanted to share this article (Pasted on my Facebook page, both personal and organizational). integrativepractitioner.com...

[jdm3]

Thanks. It's always good to know that a supplement I take continues to get positive reviews. Interesting that they say "non-metastatic biochemical relapse." I wonder what means for most of here who are metastatic.

Going to NC tomorrow for a meeting. It looks like pretty crappy weather.

Take care and happy new year to all.

[CrocodileShoes]

Wow, that is impressive. Anyone know where it can be bought?

[snoraste]

Patrick,

The recommended dose seems arbitrary to me. Do you know if there’s any science behind it?

[45yrsDenmark]

What are the other 4 supplements in your top 5?

[Blueslover in reply to 45yrsDenmark]

Did you get a reply on the other 4 top supplements? Would love to get that information

Hugh

[45yrsDenmark]

Isn't the effect (reduction of metastases) only shown on PCa patients with locally non-metastatic PCa?

[45yrsDenmark in reply to 45yrsDenmark]

Hmm So when also on Zytiga to be taken on empty stomach for a 3 hour period (2 hours and also 1 hour after), it seems to be quite a logistic job to also fit in 3x MCP a day on empty stomach.. and also when on prednisone twice a day in connection with meal, Ca-tablets and other nutraceuticals (IP6 etc)... it seems difficult to follow this daily intakes each day in the long run?

[Hidden in reply to 45yrsDenmark]

Its a lot . I’ve done it over four years now . Although my nat dr halted the Mcp a few years back I still take many others.

[Ramp7]

I have been taking this for about a month but only a small measure each morning. Maybe I should increase the dose.

[sedgley]

Is there any evidence of benefit in relation to disease which is already metastatic?

[pjoshea13 in reply to sedgley]

I'm inclined to believe that it is always worthwhile to inhibit further colonization. If there are PCa cells in circulation, it's a good idea to target them.

-Patrick

[sedgley in reply to pjoshea13]

Thanks Patrick.

[snoraste]

Nal,

I read the original Israeli report and started taking it ever since my diagnosis. My question is why 15g/day? was it ever tested for 5g or 30g? Is there a (reasonable) scientific reason why we think 15g should be the right dosage? I started taking 5g 3x a day, and now I'm 7.5g 2x day (for convenience).

[Ramp7]

I just noticed the empty stomach instructions. Shall have to modify my approach. Thanks

[mrssnappy]

When I first started researching MCP I came across this article from 2007 comparing MCP and fractionated pectin powder. Do you know if there have been any follow-up studies on this topic? academic.oup.com/glycob/art...

[pjoshea13 in reply to mrssnappy]

My goodness! It's almost 13 years since I contacted Debra Mohnen & asked her for the full text. Debra & her team were not interested in cancer, particularly. Their field is/was pectin (they work in the Complex Carbohydrate Research Center, Department of Biochemistry and Molecular Biology, The University of Georgia, Athens.) She was astonished by the number of requests she had received from men with PCa.

I was quite excited by the paper & contacted the head of research at Thorne. He was unaware that there had been a study!!! I sent him the paper & that was the end of that. Thorne didn't promote their version, which was clearly superior in the study. It was never used in human trials. Eventually, Thorne stopped making the stuff & started selling the EcoNugenics product. They used the terms "fractionated" & "modified" interchangeably for a while & some guys felt ripped-off when MCP arrived in the mail.

-Patrick

[mrssnappy in reply to pjoshea13]

Thank you Patrick. I think I finally understand it now.

[Ramp7]

I could see that, taste pretty good. I've been adding to a small glass of water. I'll have to try your method.

[Nirman]

What are other 4 supplements?

[Hidden]

I used it every day religiously for two years until my nat md told me to drop it . I think it did me some good . However it was a Pain in the butt mixing and drinking that stuff .

[Hidden]

Hard Corp Nal 😂

[Hidden]

You can’t please all of the people all of the time. If you just helped one person that is great . You help many.. 🙏